Publications associées à Structural and functional brain imaging using extended-focus optical coherence tomography and microscopy

Publications associées (40)

Simulation-based Microstructure Imaging: Towards Realistic White Matter Modeling using Monte Carlo Methods in DW-MRI

Over the last two decades, Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) has been developed as a powerful MR imaging modality that allows estimating non-invasively the microscopic structure of biological tissues by exploiting the natural motion of ...

EPFL2025

Functional-based parcellation of the mouse prefrontal cortex for network perturbation analysis

Christina Maria Grimm

The prefrontal cortex (PFC) is a brain region involved in higher-order cognitive processes such as attention, emotional regulation, and social behavior. However, the delineation of distinct subdivisions within the mouse PFC and their contributions to the b ...

2025

Fast Quantification of Creatine Kinase Activity by Phosphorus Magnetic Resonance Fingerprinting

Mark Stephan Widmaier

A novel fast 3D-31P-B+1 mapping method called the frequency-selective Double-AngleMethod (fDAM) has been developed. This method integrates a 3D weighted stack of spiral gradient echo acquisitions with a frequency-selective pulse to efficiently map B+1 fiel ...

EPFL2025

Reward signals in the motor cortex: from biology to neurotechnology

Solaiman Shokur, Pierre Theopistos Vassiliadis

Over the past decade, research has shown that the primary motor cortex (M1), the brain's main output for movement, also responds to rewards. These reward signals may shape motor output in its final stages, influencing movement invigoration and motor learni ...

NATURE PORTFOLIO2025

Towards personalized mapping through lumbosacral spinal cord task fMRI

Dimitri Nestor Alice Van De Ville, Nawal Noëlle Kinany, Ilaria Ricchi

The lumbosacral spinal cord contains neural circuits crucial for locomotion, organized into rostrocaudal levels with distinct somatosensory and motor neuron pools that project to and from the muscles of the lower limbs. However, the specific spinal levels ...

2025

Pre-movement sensorimotor oscillations shape the sense of agency by gating cortical connectivity

Olaf Blanke, Bruno Herbelin, Nathaniel Evans, Bastien Orset

Our sense of agency, the subjective experience of controlling our actions, is a crucial component of self-awareness and motor control. It is thought to originate from the comparison between intentions and actions across broad cortical networks. However, th ...

2025

Morphodynamics of human early brain organoid development

Matthias Lütolf, Antonius Chrisnandy

Brain organoids enable the mechanistic study of human brain development and provide opportunities to explore self-organization in unconstrained developmental systems1, 2–3. Here we establish long-term, live light-sheet microscopy on unguided brain organoid ...

Springer Science and Business Media LLC2025

Correlative light and electron microscopy for human brain and other biological models

Cornelius Laurentius Matheus van den Heuvel, Henning Paul-Julius Stahlberg, Marta Di Fabrizio, Amanda Jennifer Lewis, Christel Genoud, Notash Shafiei, Domenic Burger, Daniel Andrea Constantin Stähli

Correlative light and electron microscopy (CLEM) combines light microscopy, for identifying a target via genetic labels, dyes, antibodies and morphological features, with electron microscopy, for analyzing high-resolution subcellular ultrastructures. Here, ...

Nature Publishing Group2025

The Interdisciplinary Synergy Between Neurology and Psychiatry: Advancing Brain Health

Umberto Nencha

The study of brain disorders has long been central to both neurology and psychiatry, with these two disciplines evolving as distinct yet deeply interconnected fields. In fact, these specialties often share overlapping symptoms, neural pathways, and treatme ...

MDPI AG2025

Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation

Simone Romeni, Valeria De Seta

Restoring the ability to walk is a priority for individuals with neurological disorders or neurotraumatic injuries, given its significant impact on independence and quality of life. Multimodal closed-loop strategies that integrate robotic assistance and ne ...

2025

Driving and suppressing the human language network using large language models

Martin Schrimpf

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

Nature Portfolio2024

Subcortical correlates of consciousness with human single neuron recordings

Olaf Blanke, Fosco Bernasconi, Nathan Quentin Faivre, Michael Eric Anthony Pereira

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...

Wiley2024

Advanced Silicon and SWIR Single-Photon Avalanche Diodes: Design, Simulation, and Characterization

Ekin Kizilkan

Low-level light detection with high spatial and timing accuracy is a growing area of interest by virtue of applications such as light detection and ranging (LiDAR), biomedical imaging, time-resolved Raman spectroscopy, and quantum applications. Single-phot ...

EPFL2024

Dissipative Kerr soliton generation at 2μm in a silicon nitride microresonator

Camille Sophie Brès, Marco Clementi, Ozan Yakar, Anton Stroganov, Christian André Clément Lafforgue

Chip -scale optical frequency combs enable the generation of highly -coherent pulsed light at gigahertz-level repetition rates, with potential technological impact ranging from telecommunications to sensing and spectroscopy. In combination with techniques ...

Optica Publishing Group2024

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Mohammad Javad Karimi

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

EPFL2024

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

An immersive virtual reality tool for assessing left and right unilateral spatial neglect

Olaf Blanke, Andrea Serino, Roberta Ronchi

The reported rate of the occurrence of unilateral spatial neglect (USN) is highly variable likely due to the lack of validity and low sensitivity of classical tools used to assess it. Virtual reality (VR) assessments try to overcome these limitations by pr ...

Wiley2024

Silicon CMOS and InGaAs(P)/InP SPADs for NIR/SWIR detection

Utku Karaca

Applications demanding imaging at low-light conditions at near-infrared (NIR) and short-wave infrared (SWIR) wavelengths, such as quantum information science, biophotonics, space imaging, and light detection and ranging (LiDAR), have accelerated the develo ...

EPFL2024

White adipose tissue distribution and amount are associated with increased white matter connectivity

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Wiley2024