Publications associées à Modelling the Intracellular Environment under Uncertainty, from Post-translational Modification to Metabolic Networks

Publications associées (38)

PolyCLEAN: Atomic optimization for super-resolution imaging and uncertainty estimation in radio interferometry

Julien René Fageot, Matthieu Martin Jean-André Simeoni, Sepand Kashani, Adrian Thibault Etienne Jarret, Joan Rue Queralt

Context. Imaging in radio interferometry requires solving an ill-posed noisy inverse problem, for which the most adopted algorithm is the original CLEAN algorithm and its variants. Alternative explicit optimization methods have gained increasing attention, ...

EDP SCIENCES S A2025

Observation of the ${{{\varLambda } ^0_{b}} \!\rightarrow {{J \hspace{-1.66656pt}/\hspace{-1.111pt}\psi }} {{\varXi } ^-} {{K} ^+} }$ and ${{{{\varXi } ^0_{b}} \!\rightarrow {{J \hspace{-1.66656pt}/\hspace{-1.111pt}\psi }} {{\varXi } ^-} {{\pi } ^+} }}$ decays

Olivier Schneider, Aurelio Bay, Tatsuya Nakada, Frédéric Blanc, Lesya Shchutska, Elena Graverini, Marie Theres Christin Bachmayer, Ettore Zaffaroni, Aravindhan Venkateswaran, Luis Miguel Garcia Martin, Yunxuan Song, Vitalii Lisovskyi, Federico Ronchetti, Radoslav Marchevski, Anni Matilda Kauniskangas, Dimitrios Kaminaris, Raphaël van Laak, Pierre Paul Louis Mayencourt, Brianna Leililani Thielen, Arnaud Merlin Gauthey, Gianluca Zunica, Abdul-Kerim Guseinov, Roberto Ribatti, Louis André Marie Jean Henry, Spencer Edward Collaviti, Julius Christian Daniel Schulte

The first observation of the

{{{{\varXi } ^0_{b}} \!\rightarrow {{J \hspace{-1.66656pt}/\hspace{-1.111pt}\psi }} {{\varXi } ^-} {{\pi } ^+} }}

decay and the most precise measurement of the branching fraction of the ${{{\varLambda } ^0_{b}} !\rightarrow ...

Springer Science and Business Media LLC2025

Uncertainties as a Guide for Global Water Model Advancement

Sara Bonetti

Global water models allow us to explore the terrestrial water cycle in earth-sized digital laboratories to support science and guide policy. However, these models are still subject to considerable but also reducible uncertainties that can be attributed to ...

2025

Study of light-meson resonances decaying to K S0 Kπ in the B → (K S0 Kπ)K channels

Olivier Schneider, Aurelio Bay, Guido Haefeli, Tatsuya Nakada, Frédéric Blanc, Lesya Shchutska, Elena Graverini, Sebastian Schulte, Marie Theres Christin Bachmayer, Ettore Zaffaroni, Aravindhan Venkateswaran, Luis Miguel Garcia Martin, Yunxuan Song, Vitalii Lisovskyi, Sonia Amina Bouchiba, Federico Ronchetti, Radoslav Marchevski, Anni Matilda Kauniskangas, Dimitrios Kaminaris, Raphaël van Laak, Pierre Paul Louis Mayencourt, Andrea Merli, Gianluca Zunica, Abdul-Kerim Guseinov, Roberto Ribatti, Spencer Edward Collaviti

A study is presented of B+→KS0K-π+K+ and B+→KS0K+π-K+ decays based on the analysis of proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb-1. The KS0K ...

2025

Branching fraction measurement of the decay B+→ψ(2S)ϕ(1020)K+

Olivier Schneider, Aurelio Bay, Guido Haefeli, Tatsuya Nakada, Frédéric Blanc, Lesya Shchutska, Elena Graverini, Sebastian Schulte, Marie Theres Christin Bachmayer, Serhii Cholak, Ettore Zaffaroni, Aravindhan Venkateswaran, Luis Miguel Garcia Martin, Yunxuan Song, Vitalii Lisovskyi, Sonia Amina Bouchiba, Federico Ronchetti, Radoslav Marchevski, Anni Matilda Kauniskangas, Dimitrios Kaminaris, Raphaël van Laak, Pierre Paul Louis Mayencourt, Andrea Merli, Gianluca Zunica, Abdul-Kerim Guseinov, Roberto Ribatti, Spencer Edward Collaviti

The branching fraction of the decay B + → ψ ( 2 S ) ϕ ( 1020 ) K + , relative to the topologically similar decay B + → J / ψ ϕ ( 1020 ) K + , is measured using proton-proton collision data collected by the LHCb experiment at center-of-mass energies of 7, 8 ...

American Physical Society (APS)2025

Search for the Double Dalitz Decays η/η' →e + e -μ +μ - and η'→μ+μ-μ+μ-

Yunxuan Song

Using a data sample of (10087 +/- 44)x10(6) J/psi events collected with the BESIII detector, we search for the decays eta/eta' -> e (+) e (-)mu (+)mu (-) and eta'->mu(+)mu(-)mu(+)mu(-) via the radiative decaysJ/psi ->gamma eta/gamma eta '. No excess of eve ...

AMER PHYSICAL SOC2025

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Anthony Marchand

Proteins are foundational biomolecules of life playing a crucial role in a myriad of biological processes. Their function often requires interplay with other biomolecules, including proteins themselves. Protein-protein interactions (PPIs) are essential for ...

EPFL2024

Precision luminosity measurement at hadron colliders

Joanna Malgorzata Wanczyk

This thesis links two realms of particle accelerator dynamics and precision particle physics. The achievement of precise luminosity measurement at hadron colliders is enabled with dedicated luminometers. For the Run 3 period, the luminometer upgrade was ...

EPFL2024

Design of an Open-Loop Pile-Oscillation Program in the CROCUS Reactor

Andreas Pautz, Vincent Pierre Lamirand, Axel Guy Marie Laureau, Thomas Jean-François Ligonnet

As a follow-up to the CEA-EPFL PETALE experimental program on stainless steel nuclear data, the EPFL initiated an open-loop pile-oscillation experimental program in the CROCUS reactor: BLOOM. A reproduction of the critical experiments of PETALE, the progra ...

2024

Climbing into their Skin to Understand Contextual Protein-Protein Associations and Localizations: Functional Investigations in Transgenic Live Model Organisms

Yimon Aye

Borrowing some quotes from Harper Lee's novel "To Kill A Mockingbird" to help frame our manuscript, we discuss methods to profile local proteomes. We initially focus on chemical biology regimens that function in live organisms and use reactive biotin speci ...

Wiley-V C H Verlag Gmbh2024

Quantifying the Unknown: Data-Driven Approaches and Applications in Energy Systems

Paul Scharnhorst

In light of the challenges posed by climate change and the goals of the Paris Agreement, electricity generation is shifting to a more renewable and decentralized pattern, while the operation of systems like buildings is increasingly electrified. This calls ...

EPFL2024

Mechanisms and functions of protein S-acylation

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento Ribeiro De Mesquita

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

Nature Portfolio2024

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Mahdi Hijazi

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

EPFL2024

Toward Reliable Human Pose Forecasting With Uncertainty

Alexandre Massoud Alahi, Saeed Saadatnejad, Taylor Ferdinand Mordan

Recently, there has been an arms race of pose forecasting methods aimed at solving the spatio-temporal task of predicting a sequence of future 3D poses of a person given a sequence of past observed ones. However, the lack of unified benchmarks and limited ...

2024

Federated learning with uncertainty-based client clustering for fleet-wide fault diagnosis

Olga Fink, Hao Lu

Operators from various industries have been pushing the adoption of wireless sensing nodes for industrial monitoring, and such efforts have produced sizeable condition monitoring datasets that can be used to build diagnosis algorithms capable of warning ma ...

2024

Charge-Transfer States in Organic Nanowires

Lucile Annie Chassat

Charge separation processes in organic semiconductors play a pivotal role in diverse applications ranging from photovoltaics to photocatalysis. Understanding these mechanisms, particularly the role of hybrid charge-transfer (CT) states, is essential for ad ...

EPFL2024

Reconstruction and analysis of genome-scale metabolic networks in single organisms and microbial communities

Evangelia Vagena

Microorganisms are a key component in the chain of life. They are essential for agriculture, produce a large proportion of oxygen, and play a central role in the cycle of elements. Microorganisms are widely used in the production of food and alcoholic beve ...

EPFL2024

Extensions of Peer Prediction Incentive Mechanisms

Adam Julian Richardson

As large, data-driven artificial intelligence models become ubiquitous, guaranteeing high data quality is imperative for constructing models. Crowdsourcing, community sensing, and data filtering have long been the standard approaches to guaranteeing or imp ...

EPFL2024

Computational drug development for membrane protein targets

Pierre Vogel, Henning Paul-Julius Stahlberg, Shuguang Yuan, Dongchun Ni, Babatunde Edukpe Ekundayo

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

2024

ZigZag: Universal Sampling-free Uncertainty Estimation Through Two-Step Inference

Minh Hieu Lê, Nikita Durasov

Whereas the ability of deep networks to produce useful predictions on many kinds of data has been amply demonstrated, estimating the reliability of these predictions remains challenging. Sampling approaches such as MC-Dropout and Deep Ensembles have emerge ...

2024