Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice

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Objective: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early stage of Parkinson's disease or related disorders. Diagnosis requires an overnight video-polysomnogram (vPSG), however, even for sleep experts, interpre ...

Over the past decade, research has shown that the primary motor cortex (M1), the brain's main output for movement, also responds to rewards. These reward signals may shape motor output in its final stages, influencing movement invigoration and motor learni ...

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CR ...

Human motor skill acquisition is improved by performance feedback, and coupling such feedback with extrinsic reward (such as money) can enhance skill learning. However, the neurophysiology underlying such behavioral effect is unclear. To bridge this gap, w ...

Our sense of agency, the subjective experience of controlling our actions, is a crucial component of self-awareness and motor control. It is thought to originate from the comparison between intentions and actions across broad cortical networks. However, th ...

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

Recent advances in volume electron microscopy (EM) have been driving our thorough understanding of the brain architecture. Volume EM becomes increasingly powerful when cells and their subcellular structures that are imaged in light microscopy are correlate ...

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...

This dataset contains some images (TIFF image data) of brain juvenile rats Wistar Han (P14) scanned immunostained slides by using an automated slide scanner (Olympus, VS120-L100, GER) equipped with a UPLSAPO 20x/0.75 air objective (Olympus, GER) and a Pi ...

Time-lapse light microscopy combined with in vitro neuronal cultures has provided a significant contribution to the field of Developmental Neuroscience. The establishment of the neuronal polarity, i.e., formation of axons and dendrites, key structures resp ...

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task -driven modeling approach to investigate the neural code of p ...

Air traffic noise emissions are responsible for a significant part of the overall environmental noise, especially in the vicinity of airports. Exposure to environmental noise is known to negatively impact health and to be associated with cardiovascular dis ...

This article provides a comprehensive review of the most recent advances in the planning, execution, and analysis of inflow and wake measurements from nacelle-mounted wind Doppler lidars. Lidars installed on top of wind turbines provide a holistic view of ...

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice

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Automated Detection of Isolated REM Sleep Behavior Disorder Using Computer Vision

Reward signals in the motor cortex: from biology to neurotechnology

Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

Effect of Extrinsic Reward on Motor Plasticity during Skill Learning

Pre-movement sensorimotor oscillations shape the sense of agency by gating cortical connectivity

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas

Correlative light and volume electron microscopy to study brain development

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling

Nissl_4, Raw images for Machine learning for histological annotation and quantification of cortical layers

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Plasticity of sensory representations in the posterior insular cortex during fear learning

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

Task-driven neural network models predict neural dynamics of proprioception

Robust tunable acoustic impedance control on electroacoustic resonators for aircraft noise reduction

Characterization of wind turbine flow through nacelle-mounted lidars: a review

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays