The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

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Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

This paper presents a novel hybrid framework for generating and updating a synthetic population. We call it hybrid because it combines model-based and data-driven approaches. Existing generators produce a snapshot of synthetic data that becomes outdated ov ...

We propose a comparative study of three different methods aimed at optimizing existing groundwater monitoring networks. Monitoring piezometric heads in subsurface porous formations is crucial at regional scales to properly characterize the relevant subsurf ...

We consider optimal regimes for algorithm-assisted human decision-making. Such regimes are decision functions of measured pre-treatment variables and, by leveraging natural treatment values, enjoy a superoptimality property whereby they are guaranteed to o ...

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...

In this thesis we will present two results on global existence for nonlinear dispersive equations with data at or below the scaling regularity. In chapter 1 we take a probabilistic perspective to study the energy-critical nonlinear Schrödinger equation in ...

Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data st ...

Aerobic granular sludge (AGS) consists of a microbial consortium that has an important role in wastewater treatment. This study investigates AGS microorganisms cultivated in a laboratory-scale sequencing batch reactor. Metagenomic sequencing was conducted ...

In light of the challenges posed by climate change and the goals of the Paris Agreement, electricity generation is shifting to a more renewable and decentralized pattern, while the operation of systems like buildings is increasingly electrified. This calls ...

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Chattez avec Graph Search

Recording physiological history of cells with chemical labeling

Hybrid Simulator for Capturing Dynamics of Synthetic Populations

Data-driven statistical optimization of a groundwater monitoring network

Optimal regimes for algorithm-assisted human decision-making

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains

Probabilistic and Deterministic Wellposedness for Low Regularity Dispersive Equations

Orchestrating chromosome conformation capture analysis with Bioconductor

Microbial genome collection of aerobic granular sludge cultivated in sequencing batch reactors using different carbon source mixtures

Quantifying the Unknown: Data-Driven Approaches and Applications in Energy Systems