Publications associées à Correlation between muscular and nerve signals responsible for hand grasping in non-human primates

Publications associées (38)

Effect of Extrinsic Reward on Motor Plasticity during Skill Learning

Friedhelm Christoph Hummel, Pierre Theopistos Vassiliadis

Human motor skill acquisition is improved by performance feedback, and coupling such feedback with extrinsic reward (such as money) can enhance skill learning. However, the neurophysiology underlying such behavioral effect is unclear. To bridge this gap, w ...

2025

Towards personalized mapping through lumbosacral spinal cord task fMRI

Dimitri Nestor Alice Van De Ville, Nawal Noëlle Kinany, Ilaria Ricchi

The lumbosacral spinal cord contains neural circuits crucial for locomotion, organized into rostrocaudal levels with distinct somatosensory and motor neuron pools that project to and from the muscles of the lower limbs. However, the specific spinal levels ...

2025

A Reconfigurable High-Dynamic Range ∆Σ Front-End with Event-Based Decimation for Bandwidth-Efficient Implantable Neural Interfaces

David Atienza Alonso, Giovanni Ansaloni, Pasquale Davide Schiavone, Juan Pablo Sapriza Araujo

As the demand for high channel counts and high-resolution recordings of neural activity continues to grow, the increased power and data rate generated impose hard constraints on the telemetry capabilities of wireless implantable neural interfaces. To addre ...

IEEE2025

Deep-learning models of the ascending proprioceptive pathway are subject to illusions

Olaf Blanke, Alexander Mathis, Merkourios Simos, Adriana Perez Rotondo, Florian Axel Raphaël David

Proprioception is essential for perception and action. Like any other sense, proprioception is also subject to illusions. In this study, we model classic proprioceptive illusions in which tendon vibrations lead to biases in estimating the state of the body ...

Wiley2025

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Emilie Cornelia Maria Revol

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

EPFL2024

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Outman Akouissi

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

EPFL2024

Evaluation of antigravitational support levels provided by a passive upper-limb occupational exoskeleton in repetitive arm movements

Giulia Ramella

Upper-limb occupational exoskeletons to support the workers' upper arms are typically designed to provide antigravitational support. Although typical work activities require workers to perform static and dynamic actions, the majority of the studies in lite ...

Elsevier Sci Ltd2024

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Alessia De Masi, Keno Strotjohann

Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

Wiley2024

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

Silvestro Micera

When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the ner ...

MDPI2023

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart, Darshan Mandge, Aurélien Tristan Jaquier, Mickael Maurice Zbili

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

2024

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Dohyun Park, Johan Auwerx, Xiaoxu Li, Hao Li, Jean-David Horacio Morel, Tanes Imamura de Lima, Ludger Jan Elzuë Goeminne, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Mario Romani, Sandra Rodriguez Lopez, Changmyung Oh

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Task-driven neural network models predict neural dynamics of proprioception

Alexander Mathis, Alberto Silvio Chiappa, Alessandro Marin Vargas, Axel Bisi

Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task -driven modeling approach to investigate the neural code of p ...

Cell Press2024

Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Silvestro Micera, Fiorenzo Artoni

The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cort ...

Nature Portfolio2023

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Felix Schürmann, Daniel Keller, Eilif Benjamin Muller, Michael Reimann, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, Matthias Wolf, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Liesbeth Maria L Vanherpe, Huanxiang Lu, Daniela Egas Santander, James Bryden Isbister, Ran Levi, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere, Sirio Bolaños Puchet, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Joni Henrikki Herttuainen, Christoph Pokorny, Vishal Sood, Thomas Brice Delemontex, Adrien Michel Achille Devresse, Nicolas René Jean Ninin, Alexander Dietz, Hugo Thabo Dictus, Gianluca Ficarelli

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Martinus Adela Maria Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

eLIFE SCIENCES PUBL LTD2023

Development and evaluation of a near-infrared photovoltaic implant for wireless neural stimulation

Danashi Imani Medagoda

Neural implants have demonstrated efficacy in implementing therapies for neurological disorders but their rigid design often leads to complications due to the mechanical mismatch with soft neural tissue. Current research focuses on developing flexible elec ...

EPFL2024

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Auke Ijspeert

Animal locomotion is the result of complex and multi-layered interactions between the nervous system, the musculo-skeletal system and the environment. Decoding the underlying mechanisms requires an integrative approach. Comparative experimental biology has ...

Company Biologists Ltd2023

Robust gamma-aminobutyric acid and energy metabolism measurements by proton and phosphorus magnetic resonance spectroscopy and fingerprinting

Songi Lim

Magnetic resonance spectroscopy (MRS) is the only technique that can detect endogenous metabolites directly and non-invasively in vivo. It allows to identify different metabolites and analyze the dynamic neurochemical processes in the brain, skeletal muscl ...

EPFL2023

33.3 MiBMI: A 192/512-Channel 2.46mm² Miniaturized Brain-Machine Interface Chipset Enabling 31-Class Brain-to-Text Conversion Through Distinctive Neural Codes

Mahsa Shoaran, Uisub Shin, Mohammad Ali Shaeri, Amitabh Yadav

Recently, cutting-edge brain-machine interfaces (BMIs) have revealed the potential of decoders such as recurrent neural networks (RNNs) in predicting attempted handwriting [1] or speech [2], enabling rapid communication recovery after paralysis. However, c ...

IEEE2024

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

Felix Schürmann, Michael Reimann, Armando Romani, Huanxiang Lu, Sirio Bolaños Puchet, Juan Bautista Hernando Vieites, Aleksandra Zuzanna Teska

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

2024