Publications associées à Parameter extraction and classification of three cortical neuron types reveals two distinct adaptation mechanisms

Publications associées (34)

Simulation-based Microstructure Imaging: Towards Realistic White Matter Modeling using Monte Carlo Methods in DW-MRI

Over the last two decades, Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) has been developed as a powerful MR imaging modality that allows estimating non-invasively the microscopic structure of biological tissues by exploiting the natural motion of ...

EPFL2025

Convex Computation of Value-at-risk Bounds for Stochastic Processes

Matteo Raphael Tacchi

This article formulates algorithms to upper-bound the maximum value-at-risk (VaR) of a state function along trajectories of stochastic processes. The VaR is upper bounded by two methods: minimax tail-bounds (Cantelli/Vysochanskij-Petunin) and Expected Shor ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2025

Subcortical correlates of consciousness with human single neuron recordings

Olaf Blanke, Fosco Bernasconi, Nathan Quentin Faivre, Michael Eric Anthony Pereira

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart, Darshan Mandge, Aurélien Tristan Jaquier, Mickael Maurice Zbili

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

2024

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Christian Heinis, Alessandro Angelini, Alexander Lund Nielsen, Mischa Schüttel, Manuel Leonardo Merz, Xinjian Ji, Anne Sofie Luise Zarda, Ganesh Kumar Mothukuri, Zsolt Bognár, Edward Jeffrey Will

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Wiley-VCH Verlag GmbH2024

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

Silvestro Micera

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

Ieee-Inst Electrical Electronics Engineers Inc2024

The mouse motor system contains multiple premotor areas and partially follows human

Valerio Zerbi

While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher -order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we sho ...

Cell Press2024

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Felix Schürmann, Daniel Keller, Eilif Benjamin Muller, Michael Reimann, Werner Alfons Hilda Van Geit, Lida Kanari, Srikanth Ramaswamy, Matthias Wolf, James Gonzalo King, Alexis Arnaudon, Ying Shi, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Liesbeth Maria L Vanherpe, Huanxiang Lu, Daniela Egas Santander, James Bryden Isbister, Ran Levi, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere, Sirio Bolaños Puchet, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Joni Henrikki Herttuainen, Christoph Pokorny, Vishal Sood, Thomas Brice Delemontex, Adrien Michel Achille Devresse, Nicolas René Jean Ninin, Alexander Dietz, Hugo Thabo Dictus, Gianluca Ficarelli

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Multimodal transcriptomic atlases of mouse spinal cord injury

Matthieu Pierre Gautier

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

Felix Schürmann, Michael Reimann, Armando Romani, Huanxiang Lu, Sirio Bolaños Puchet, Juan Bautista Hernando Vieites, Aleksandra Zuzanna Teska

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

2024

Numerical investigation of two-dimensional Mode-II delamination in composite laminates

Thomas Keller, Anastasios Vassilopoulos, Congzhe Wang

Existing standards for delamination tests on composite materials typically employ one-dimensional (1D) beam specimens. However, such specimens may not represent real delamination scenarios in composite structures, where cracks tend to propagate in two dime ...

Elsevier Sci Ltd2024

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Emilie Cornelia Maria Revol

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

EPFL2024

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Maria del Carmen Sandi Perez, Elias Georges Gebara

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Springer2024

Fluorogenic polymethine dyes by intramolecular cyclization

Pablo Rivera Fuentes, Annabell Martin

Fluorescence imaging plays a pivotal role in the study of biological processes, and cell -permeable fluorogenic dyes are crucial to visualize intracellular structures with high specificity. Polymethine dyes are vitally important fluorophores in singlemolec ...

Elsevier Sci Ltd2024

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Farnaz Delavari

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Wiley2024

Ready-to-Record Cells for Kinetic Screening of VGICs

Rajnish Ranjan, Emmanuelle Logette

Voltage-gated ion channels (VGICs) are integral membrane proteins crucial for transmitting electrical signals in excitable cells. Understanding the kinetics of these ion channels requires conducting patch-clamp experiments using genetically modified cell l ...

2024

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

Carl Petersen, Sylvain Crochet, Aurélie Pala, Taro Kiritani, Célia Roxane Gasselin

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

PUBLIC LIBRARY SCIENCE2023

Striatal Dopamine Signals and Reward Learning

Meriam Malekzadeh, Robin François Virginien Dard, Carl Petersen, Sylvain Crochet, Yanqi Liu, Parviz Ghaderi, Christos Sourmpis, Pol Bech Vilaseca, Mauro Pulin, Anthony Pierre Robert Renard

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Oxford Univ Press2023

From Surfactants to 3D Printing: How Ion-Chelator Pair Interactions Affect the Mechanical Properties of Bioinspired Materials

Gaia De Angelis

The remarkable adaptability observed in marine ecosystems has often inspired researchers when developing new soft materials. The research undertaken in this thesis explores how ion chelator pair interactions influence the mechanical properties of bioinspir ...

EPFL2024

Nissl_4, Raw images for Machine learning for histological annotation and quantification of cortical layers

Julie Meystre

This dataset contains some images (TIFF image data) of brain juvenile rats Wistar Han (P14) scanned immunostained slides by using an automated slide scanner (Olympus, VS120-L100, GER) equipped with a UPLSAPO 20x/0.75 air objective (Olympus, GER) and a Pi ...

Zenodo2024