Publications associées à Platform-wide Deadlock Immunity for Mobile Phones

TEEzz: Fuzzing Trusted Applications on COTS Android Devices

Security and privacy-sensitive smartphone applications use trusted execution environments (TEEs) to protect sensitive operations from malicious code. By design, TEEs have privileged access to the entire system but expose little to no insight into their inn ...

IEEE COMPUTER SOC2023

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes

Myriam Isabelle Lamrayah

Vaccine technology is still facing challenges regarding some infectious diseases, which can be addressed by innovative drug delivery systems. In particular, nanoparticle-based vaccines combined with new types of adjuvants are actively explored as a platfor ...

MDPI2023

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

Myriam Isabelle Lamrayah

Hepatitis B virus remains a major medical burden with more than 250 million chronically infected patients worldwide and 900,000 deaths each year, due to the disease progression towards severe complications (cirrhosis, hepatocellular carcinoma). Despite the ...

ELSEVIER2023

Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

Didier Trono, Céline Pellaton, Madeleine Suffiotti

IMPORTANCE There are limited comparative data on the durability of neutralizing antibody (nAb) responses elicited by messenger RNA (mRNA) vaccines against the SARS-CoV-2 variants of concern (VOCs) in immunocompromised patients and healthy controls. ...

AMER MEDICAL ASSOC2022

Too Quiet in the Library: An Empirical Study of Security Updates in Android Apps' Native Code

Mathias Josef Payer

Android apps include third-party native libraries to increase performance and to reuse functionality. Native code is directly executed from apps through the Java Native Interface or the Android Native Development Kit. Android developers add precompiled nat ...

IEEE COMPUTER SOC2021

Delivery of STING agonists for adjuvanting subunit vaccines

Li Tang, Bing Feng, Simon Bart M. Van Herck

Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen recognition receptors have been developed as potent adjuvants to optimize the immunogenicity and efficacy of vaccines. Recently discovered cyclic GMP-AMP synthase-stimulator ...

ELSEVIER2021

Just-in-time performance without warm-up

Denys Shabalin

Scala has been developed as a language that deeply integrates with the Java ecosystem. It offers seamless interoperability with existing Java libraries. Since the Scala compiler targets Java bytecode, Scala programs have access to high-performance runtimes ...

EPFL2020

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Alexandre de Titta, Witold Waldemar Kilarski, Sachiko Hirosue, Marcela Rincón-Restrepo, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

Li Tang, Lixia Wei, Yu Zhao, Xiaomeng Hu

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigen ...

2020

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

Francesco Stellacci

The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. ...

AMER CHEMICAL SOC2020

Safe initialization of objects

Fengyun Liu

The inception of object-oriented programming introduces a category of bugs related to object construction: initialization errors. Every newly created object goes through several initialization states: starting from a state where all fields are uninitialize ...

EPFL2020

Atomic-Scale Description of Interfaces between Antigen and Aluminum-Based Adjuvants Used in Vaccines by Dynamic Nuclear Polarization (DNP) Enhanced NMR Spectroscopy

David Benjamin Roger Antoine Gajan, Federico Maria Paruzzo, Jasmine Viger-Gravel

The addition of aluminum-based adjuvants in vaccines enhances the immune response to antigens. The strength of antigen adsorption on adjuvant gels is known to modulate vaccine efficacy. However, a detailed understanding of the mechanisms of interaction bet ...

WILEY-V C H VERLAG GMBH2020

Privacy-Enhancing Technologies for Mobile Applications and Services

Thi Van Anh Pham

Over a third of the world 's population owns a smartphone. As generic computing devices that support a large and heterogeneous collection of mobile applications (apps), smartphones provide a plethora of functionalities and services to billions of users. B ...

EPFL2019

HideMyApp: Hiding the Presence of Sensitive Apps on Android

Jean-Pierre Hubaux, Kévin Clément Huguenin, Thi Van Anh Pham, Italo Ivan Dacosta Petrocelli, John Stephan, Eleonora Losiouk

Millions of users rely on mobile health (mHealth) apps to manage their wellness and medical conditions. Although the popularity of such apps continues to grow, several privacy and security challenges can hinder their potential. In particular, the simple fa ...

Proceedings of the 28th USENIX Security Symposium2019

HideMyApp : Hiding the Presence of Sensitive Apps on Android

Jean-Pierre Hubaux, Kévin Clément Huguenin, Thi Van Anh Pham, Italo Ivan Dacosta Petrocelli, John Stephan, Eleonora Losiouk

Millions of users rely on mobile health (mHealth) apps to manage their wellness and medical conditions. Although the popularity of such apps continues to grow, several privacy and security challenges can hinder their potential. In particular, the simple fa ...

2019

HideMyApp : Hiding the Presence of Sensitive Apps on Android

Jean-Pierre Hubaux, Kévin Clément Huguenin, Italo Ivan Dacosta Petrocelli, John Stephan, Eleonora Losiouk

Millions of users rely on mobile health (mHealth) apps to manage their wellness and medical conditions. Although the popularity of such apps continues to grow, several privacy and security challenges can hinder their potential. In particular, the simple fa ...

USENIX ASSOC2019

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Laura Jeanbart, Xavier Fredy René Quaglia-Thermes, David Scott Wilson, Giacomo Olimpio Diaceri, Maria Anna Sofia Broggi, Michal Mateusz Raczy, Ruyi Wang

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man-TLR7), which, when conjugated to antige ...

NATURE PUBLISHING GROUP2019

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Kaltrina Paloja, Maartje Martina Cornelia Bastings, Alice Comberlato

Most vaccines developed today include only the antigens that best stimulate the immune system rather than the entire virus or microbe, which makes vaccine production and use safer and easier, though they lack potency to induce acceptable immunity and long- ...

Royal Society of Chemistry2019

Cross-Platform Language Design

Sébastien Jean R Doeraene

Programming languages are increasingly compiled to multiple runtimes, each featuring their own rich structures such as their object model. Furthermore, they need to interact with other languages targeting said runtimes. A language targeting only one runtim ...

EPFL2018

Interflow: interprocedural flow-sensitive type inference and method duplication

Martin Odersky, Denys Shabalin

Scala heavily relies on a number of object-oriented abstractions to support its feature-rich collections library. There are known techniques that optimize those abstractions away in just-in-time (JIT) compilers, but applying them in the ahead-of-time (AOT) ...

2018