Simulations to study spatial extent of stimulation and effect of electrode–tissue gap in subretinal implants

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Glaucoma is one of the leading causes of irreversible blindness worldwide. Glaucoma is defined clinically as the presence of optic nerve head (ONH) degeneration and progressive loss of retinal ganglion cells (RGCs). Intra-ocular pressure (IOP) has been con ...

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

Objective: To investigate the effects of transcutaneous spinal direct current stimulation (tsDCS) on spinal cord excitability using neurophysiological methods. Methods: Spinal cord motoneuron excitability was assessed using various neurophysiological techn ...

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

Retinal prostheses hold potential for artificial vision in blind people. Here, authors show that POLYRETINA, a large and high-density photovoltaic epiretinal device, restores light-evoked cortical responses in blind Gottingen minipigs at safe irradiance le ...

Technological progress in materials science and microengineering along with new discoveries in neuroscience have contributed to restore lost or impaired sensory functions by closely interfacing with the nervous system. Electronic devices have begun to be i ...

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

The concomitant occurrence of tissue growth and organization is a hallmark of organismal development(1-3). This often means that proliferating and differentiating cells are found at the same time in a continuously changing tissue environment. How cells ada ...

We derived computationally efficient average response models of different types of cortical neurons, which are subject to external electric fields from Transcranial Magnetic Stimulation. We used 24 reconstructions of pyramidal cells (PC) from layer 2/3, 24 ...

Transient electronics enabling devices to safely disappear in the environment can be applied not only in green electronics, but also in bioelectronic medicine. Neural implants able to degrade harmlessly inside the body eliminate the need for removal surger ...

Recently, flexible and soft bioelectronic interfaces have been proposed as a solution to improve existing neural interfaces that currently present mechanical mismatch with the soft tissue. These are devices fabricated with thin polymeric or elastomeric bac ...

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a common and distant ground electrode. This configuration leads to a wide spreading of the electric field. Therefore, this approach is suboptimal for intraneural nerve ...

Visual estimates of stimulus features are systematically biased toward the features of previously encountered stimuli. Such serial dependencies have often been linked to how the brain maintains perceptual continuity. However, serial dependence has mostly b ...

Capturing the surface-structural dynamics of metal electrocatalysts under certain electrochemical environments is intriguingly desired for understanding the behavior of various metal-based electrocatalysts. However, in situ monitoring of the evolution of a ...

Micro- nano-electrodes have demonstrated superior performances in measuring attenuated intracellular action potentials from electrogenic cell cultures compared to traditional multi-electrode arrays. Yet, the understanding of the critical electrode features ...

The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing to deaf patients by electrically stimulating the cochlear nucleus (CN) of the brainstem. Whether such stimulation activates one or the other of the CN's two major sub ...

"Ensure healthy lives and promote well-being for all at all ages" is the third sustainable development goal for the United Nations Agenda of 2030. This doctoral thesis fully embodied this objective by targeting stroke, a leading cause of death and disabili ...

All functions we use in our everyday life depend on a complex interplay between both cortical and subcortical brain areas, communicating in between each others. When a region is affected by either an accident, aging or neurodegenerative diseases, the whole ...

Simulations to study spatial extent of stimulation and effect of electrode–tissue gap in subretinal implants

Chattez avec Graph Search

Neuroprotection in the Retina: From Preventing Inflammatory Cell Death to Promoting Vascular Stability in the Central Nervous System

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Effects of cervical transcutaneous spinal direct current stimulation on spinal excitability

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

POLYRETINA restores light responses in vivo in blind Gottingen minipigs

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Neuronal migration prevents spatial competition in retinal morphogenesis

Directional sensitivity of cortical neurons towards TMS induced electric fields

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

Conformable neural interfaces : from engineering stretchability at the micro-scale to translational applications

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation

Stronger serial dependence in the depth plane than the fronto-parallel plane between realistic objects: Evidence from virtual reality

In Situ Monitoring of the Surface Evolution of a Silver Electrode from Polycrystalline to Well-Defined Structures

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Combination of Neurotechnologies Towards Personalized Neurorehabilitation for Stroke Patients

Noninvasive deep brain stimulation to modulate human behavior by means of transcranial temporal interference electrical stimulation