Publications associées à Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy

Publications associées (31)

Disorder-assisted real–momentum topological photonic crystal

Romain Christophe Rémy Fleury, Haoye Qin, Zhe Zhang, Ji Zhou, Bo Li

Topological defects and disorder counteract each other. Intuitively, disorder is considered detrimental, requiring efforts to mitigate its effects in conventional topological photonics. We propose a counter-intuitive approach that exploits a real–momentum ...

Springer Science and Business Media LLC2025

Singularity with and without disorder at Affleck-Kennedy-Lieb-Tasaki points

Frédéric Mila

The Affleck-Kennedy-Lieb-Tasaki (AKLT) point of the bilinear-biquadratic spin-1 chain is a cornerstone example of a disorder point where short-range correlations become incommensurate, and correlation lengths and momenta are nonanalytic. While the presence ...

American Physical Society (APS)2025

The Interdisciplinary Synergy Between Neurology and Psychiatry: Advancing Brain Health

Umberto Nencha

The study of brain disorders has long been central to both neurology and psychiatry, with these two disciplines evolving as distinct yet deeply interconnected fields. In fact, these specialties often share overlapping symptoms, neural pathways, and treatme ...

MDPI AG2025

Highly Efficient Cardiac Differentiation and Maintenance by Thrombin-Coagulated Fibrin Hydrogels Enriched with Decellularized Porcine Heart Extracellular Matrix

Philippe Renaud, Thomas Michael Braschler, Fatemeh Navaee

Biochemical and biophysical properties instruct cardiac tissue morphogenesis. Here, we are reporting on a blend of cardiac decellularized extracellular matrix (dECM) from porcine ventricular tissue and fibrinogen that is suitable for investigations employi ...

MDPI2023

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

Jacques Fellay, Etienne Pruvot, Christian Axel Wandall Thorball

London2023

Corpus callosum structural characteristics in very preterm children and adolescents: Developmental trajectory and relationship to cognitive functioning

Dimitri Nestor Alice Van De Ville, Lorena Gonçalves de Alcântara e Freitas Krikler, Vanessa Siffredi

Previous studies suggest that structural alteration of the corpus callosum, i.e., the largest white matter commissural pathway, occurs after a preterm birth in the neonatal period and lasts across development. The present study aims to unravel corpus callo ...

ELSEVIER SCI LTD2023

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from theENIGMABipolar Disorder Working Group

Erick Jorge Canales Rodriguez, Jorge Miguel Dias Almeida Rodrigues Soares

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding ...

Wiley2022

Assessment Of Stiffness Of Large To Small Arteries In Multi-Stage Renal Disease: A Numerical Study

Nikolaos Stergiopoulos, Vasiliki Bikia

LIPPINCOTT WILLIAMS & WILKINS2022

Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support

Christian Heinis, Jonas Alfred Karl Wilbs

Blood contact with high surface area medical devices, such as dialysis and extracorporeal life support (ECLS), induces rapid surface coagulation. Systemic anticoagulation, such as heparin, is thus necessary to slow clot formation, but some patients suffer ...

ELSEVIER SCI LTD2021

Many-body localization in a fragmented Hilbert space

Loïc Jean Pierre Herviou

We study many-body localization (MBL) in a pair-hopping model exhibiting strong fragmentation of the Hilbert space. We show that several Krylov subspaces have both ergodic statistics in the thermodynamic limit and a dimension that scales much slower than t ...

2021

Impaired heart rate variability triangular index to identify clinically silent strokes in patients with atrial fibrillation

Jean-Marc Vesin

OXFORD UNIV PRESS2020

Theory of intrinsic propagation losses in topological edge states of planar photonic crystals

Juan Pablo Vasco Cano

Using a semianalytic guided-mode expansion technique, we present theory and analysis of intrinsic propagation losses for topological photonic crystal slab waveguide structures with modified honeycomb lattices of circular or triangular holes. Although conve ...

AMER PHYSICAL SOC2020

A mathematical model of the human heart

Alfio Quarteroni

In this paper, we present a mathematical model able to simulate the cardiac function. We first describe the basic physical principles behind the mathematical equations, then we illustrate a few examples of application to problems of clinical relevance. ...

PENSIERO SCIENTIFICO EDITOR2020

Coagulants of Moringa Oleifera Lam. seeds : purification & characterisation

Stephan Dörries

Water has been declared a human right by the United Nations, thus urging countries who have ratified the International Covenant on Economic, Social and Cultural Rights to ensure supply with drinking water for their populations1. However, supply of drinking ...

EPFL2005

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Christina Lamers, Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Patrick Andreas Gonschorek, Simon Jan Middendorp

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

Nature Research2020

De novo development of proteolytically resistant therapeutic peptides for oral administration

Christian Heinis, Florence Pojer, Luciano Andres Abriata, Xudong Kong, Kaycie Marie Butler, Vanessa Carle

The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal pro ...

2020

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

Jeffrey Alan Hubbell, Patrick Aebischer

Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor XIIIa was employed to covalently incorporate exogenous bioactive peptides within fibrin during c ...

2000

Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

Vanessa Carle

Hemostasis is a complex physiological process responsible for the prevention of blood loss caused by vascular injury. The dysregulation of this delicate mechanism can lead to thromboembolic diseases, the leading cause of death worldwide. Anticoagulants are ...

EPFL2019

Spherical Clustering of Users Navigating 360° Content

Pascal Frossard, Laura Toni, Francesca De Simone

In Virtual Reality (VR) applications, understanding how users explore the omnidirectional content is important to optimize content creation, to develop user-centric services, or even to detect disorders in medical applications. Clustering users based on th ...

IEEE2019

Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2

Jonas Alfred Karl Wilbs

Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...

EPFL2018