Publications associées à Correlated Optical and Electrical Single-Molecule Measurements Reveal Conformational Diffusion from Ligand Binding to Channel Gating in the Nicotinic Acetylcholine Receptor

Publications associées (9)

Neuromodulation of neocortical microcircuitry: a multi-scale framework to model the effects of cholinergic release

Neuromodulation of neocortical microcircuits is one of the most fascinating and mysterious aspects of brain physiology. Despite over a century of research, the neuroscientific community has yet to uncover the fundamental biological organizing principles un ...

EPFL2022

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Albulena Jashari-Shaqiri, Janir Nuno Ramos Antunes Da Cruz, Flavia Aurelia Shoko Hodel

Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the contributions of human genetic variations to schizophrenia, we performed a genome-wide association study (GWAS) of ...

2022

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

Henry Markram, Srikanth Ramaswamy, Cristina Colangelo

Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring netwo ...

2018

Single-Vesicle Assays Using Liposomes and Cell-Derived Vesicles: From Modeling Complex Membrane Processes to Synthetic Biology and Biomedical Applications

Ana Catarina Rodrigues Alves, Horst Arthur Vogel, Horst Pick

The plasma membrane is of central importance for defining the closed volume of cells in contradistinction to the extracellular environment. The plasma membrane not only serves as a boundary, but it also mediates the exchange of physical and chemical inform ...

AMER CHEMICAL SOC2018

X-ray structure of the mouse serotonin 5-HT3 receptor

Horst Arthur Vogel, Henning Paul-Julius Stahlberg, Rudolf Hovius, Cédric Deluz, Ghérici Hassaïne, Romain Wyss, Luigino Grasso, Menno Berend Tol

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly un ...

Nature Publishing Group2014

Predicting Adult Fish Acute Lethality with the Zebrafish Embryo: Relevance of Test Duration, Endpoints, Compound Properties, and Exposure Concentration Analysis

Kristin Schirmer

The zebrafish embryo toxicity test has been proposed as an alternative for the acute fish toxicity test, which is required by various regulations for environmental risk assessment of chemicals. We. investigated the reliability of the embryo test by probing ...

Amer Chemical Soc2012

RIM Determines Ca²+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

Yunyun Han

Fast neurotransmitter release is essential for neuron-neuron communication and is initiated by the opening of voltage-gated Ca2+ channels close to docked vesicles at the presynaptic active zone. The high concentration of Ca2+ channels at the active zone is ...

EPFL2011

Electrophysiology and fluorescence microscopy of ligand-gated ion channels

Christoph Schreiter

The thesis presented here describes studies of ligand binding, function, and arrangement of ligand-gated ion channels in cell membranes. Fluorescence microscopy and the patch clamp technique are used to investigate the nicotinic acetylcholine receptor and ...

EPFL2005

Impedance spectroscopy of ion channels in tethered lipid bilayers

Horst Arthur Vogel, Samuel Terrettaz

A review. The efficient anal. of the function of ion channels is an important task in many different fields ranging from (bio)analytics and drug-screening to nanoelectronics. Here, the modulation of the channel activity of a synthetic ligand gated ion chan ...

2005