The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression

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The role of mechanical hysteresis source in mechanical and mechanobiological performances of load-bearing biomaterials

Naser Nasrollahzadeh Mamaghani

Tissue engineering is a promising approach for articular cartilage regeneration as no satisfactory treatment is actually available for cartilage, partly due to the very limited self-healing capability of this tissue. To successfully induce a cartilaginous ...

EPFL2019

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

Omid Mashinchian

In spite of decades of research, no feasible method for obtaining sufficient numbers of uncommitted muscle stem cells (MuSCs) for therapy of degenerative muscle diseases exists. One of the most fundamental problems associated with stem cell therapy of musc ...

EPFL2019

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Matteo Gregorio Modesto Marascio, Robin Martin, Jens Antons

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2

Dominique Pioletti, Pierre-Etienne Bourban, Nathalie Hirt-Burri, Matteo Gregorio Modesto Marascio, Jens Antons, Pierre-Arnaud Aeberhard

Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercr ...

2018

Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy

Dominique Pioletti, Tanja Cloé Hausherr

Several approaches to combine bone substitutes with biomolecules, cells or mechanical loading have been explored as an alternative to the limitation and risk-related bone auto- and allo-grafts. In particular, human bone progenitor cells seeded in porous po ...

2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Andreas Schmocker, Azadeh Khoushabi, Peyman Karami, Céline Samira Wyss, Martin Broome

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

3D Printing and Supercritical Foaming of Hierarchical Cellular Materials

Matteo Gregorio Modesto Marascio

Hierarchical porous structures have been gathering interest in different fields owing to their unique properties associated with their multi-scale features. The observation of natural materials brought new insights into the functionality of cellular materi ...

EPFL2018

Adaptive numerical method algorithms for nonlinear viscous and bilinear oil damper models subjected to dynamic loading

Dimitrios Lignos

Adaptive numerical method algorithms are presented for the numerical simulation of the hysteretic behaviour of nonlinear viscous and bilinear oil dampers within a finite element program for nonlinear dynamic analysis of frame structures under earthquake ex ...

2018

Evaluation of force-based and displacement-based out-of-plane seismic assessment methods for unreinforced masonry walls through refined model simulations

Katrin Beyer, Michele Godio

The performance of force-based and displacement-based seismic assessment methods for the life-safety limit state check of out-of-plane loaded unreinforced masonry walls is evaluated on the basis of refined numerical simulations. For this purpose, a discret ...

2018

Particle-Based Numerical Manifold Method to Model Dynamic Fracture Process in Rock Blasting

Jian Zhao, Qianbing Zhang, Xing Li

A particle-based numerical manifold method (PNMM) is developed to investigate rock fracturing behavior under dynamic loading. The basic idea of PNMM is to represent the microstructure of rock with a group of particles and to simulate the macroscopic behavi ...

Asce-Amer Soc Civil Engineers2017

Cartilage self-heating contributes to chondrogenic expression

Dominique Pioletti, Philippe Abdel Sayed, Arne Christian Vogel, Mohamadreza Nassajian Moghadam

Articular cartilage is a soft tissue showing inelastic properties. Under cyclic loading, inelastic materials may dissipate mechanical energy into heat. In knee cartilage, due to an intrinsic reduced heat convection related to its avascularity, a local temp ...

European Cells & Materials Ltd2013