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Albert Dominguez Mantes

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Publications associées (4)

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Neural ADMIXTURE for rapid genomic clustering

Albert Dominguez Mantes

Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...

SPRINGERNATURE2023

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Emine Berna Durmus, Suliana Manley, Joachim Lingner, Gioele La Manno, Martin Weigert, Irina Khven, Can Aztekin, Eftychia Kyriacou, Albert Dominguez Mantes, Anjalie Olivia Schläppi, Georgios Tsissios, Evangelia Skoufa

Identification of spot-like structures in large, noisy microscopy images is a crucial step for many life-science applications. Imaging-based spatial transcriptomics (iST), in particular, relies on the precise detection of millions of transcripts in low sig ...

Nature Publishing Group2025

Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations

Maxine Leonardi, Alessandro Valente, Felix Naef, Gioele La Manno, Irina Khven, Alex Russell Lederer, Colas Noé Droin, Lorenzo Talamanca, Albert Dominguez Mantes, Antonio Herrera Camacho

Across biological systems, cells undergo coordinated changes in gene expression, resulting in transcriptome dynamics that unfold within a low-dimensional manifold. While low-dimensional dynamics can be extracted using RNA velocity, these algorithms can be ...

Nature Publishing Group2024

Archetypal Analysis for population genetics

Albert Dominguez Mantes

The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse, large ...

PUBLIC LIBRARY SCIENCE2022