Albert Dominguez Mantes

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Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...

Identification of spot-like structures in large, noisy microscopy images is a crucial step for many life-science applications. Imaging-based spatial transcriptomics (iST), in particular, relies on the precise detection of millions of transcripts in low sig ...

Across biological systems, cells undergo coordinated changes in gene expression, resulting in transcriptome dynamics that unfold within a low-dimensional manifold. While low-dimensional dynamics can be extracted using RNA velocity, these algorithms can be ...

The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse, large ...

Albert Dominguez Mantes

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Neural ADMIXTURE for rapid genomic clustering

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations

Archetypal Analysis for population genetics