Publications de Antoine Jalil | EPFL Graph Search

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Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7 alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel diseas ...

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject. ...

Antoine Jalil

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Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Asparagine protects pericentral hepatocytes during acute liver injury

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

An antibiotic and a microorganism having bile acid 7α-dehydroxylation activity for treating non-infectious diseases

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

The Bile Acid Receptor Tgr5 Regulates The Composition And Hematopoietic Support Capacity Of The Bone Marrow Microenvironment