Publications de Qi Wang | EPFL Graph Search

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Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD+) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carb ...

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has be ...

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demo ...

Qi Wang

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Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Cyclo(His-Pro): A further step in the management of steatohepatitis

A lysosomal surveillance response to stress extends healthspan

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease