Publications de Jakob Josef Langer

Publications associées (5)

Bioengineering of morphologically and functionally accurate in vitro intestinal models

Organoids are stem cell-derived 3D mimetics of tissues and organs, representing an invaluable tool for modelling tissue homeostasis and disease biology, holding great potential for drug development and clinical applications. However, organoid formation rel ...

EPFL2025

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

Matthias Lütolf, Freddy Radtke, Nicolas Antoine Vincent Broguiere, Luis Francisco Lorenzo Martin, Tania Hübscher, Amber Dawn Bowler, Jakob Josef Langer, Lucie Carrié Tillard

Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of both tumour and microenvironmental structures 1-3 . This has enabled better modelling of low-complexity cancer ...

NATURE PORTFOLIO2024

Thymic epithelial organoids mediate T-cell development

Matthias Lütolf, Tania Hübscher, Jakob Josef Langer, Lucie Carrié Tillard

Although the advent of organoids has opened unprecedented perspectives for basic and translational research, immune system-related organoids remain largely underdeveloped. Here, we established organoids from the thymus, the lymphoid organ responsible for T ...

2024

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs

Matthias Lütolf, Jakob Josef Langer

c-MAF, highly expressed in villus small intestinal enterocytes, coordinates transcriptional programs for nutrient absorption. Enterocyte-specific c-MAF inactivation impairs dietary lipid handling but also leads to tuft cell expansion and adaptive gut lengt ...

ROCKEFELLER UNIV PRESS2022

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Jakob Josef Langer, Lucie Carrié Tillard

Existing organoid models fall short of fully capturing the complexity of cancer because they lack sufficient multicellular diversity, tissue-level organization, biological durability and experimental flexibility. Thus, many multifactorial cancer processes, ...

2024