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Leonie Kolmar

Cette personne a quitté l’EPFL

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Publications associées (4)

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Droplet microfluidic platforms for multiplexed library-against-library antibody screening

Leonie Kolmar

The discovery of new therapeutic antibodies plays a crucial role in modern medicine, with monoclonal antibodies representing the majority of the 10 best-selling drugs in the world today. These antibodies are used to treat various diseases, including infect ...

EPFL2025

Technological and computational advances driving high-throughput oncology

Blandine Anne Catherine Vergier, Christoph Merten, Alexis Louis Autour, Leonie Kolmar, Xiaoli Ma

Engineering and computational advances have opened many new avenues in cancer research, particularly when being exploited in interdisciplinary approaches. For example, the combination of microfluidics, novel sequencing technologies, and computational analy ...

ELSEVIER SCIENCE LONDON2022

Improved microfluidic transcriptome based screening methods

Christoph Merten, Leonie Kolmar, Xiaoli Ma, Hongxing Hu

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

2024

Targeted barcoding of variable antibody domains and individual transcriptomes of the human B-cell repertoire using Link-Seq

Leonie Kolmar, Xiaoli Ma, Hongxing Hu

Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based on 3 ' barcoding of the transcriptome and subsequen ...

OXFORD UNIV PRESS2025