Publications de Yi Zhao | EPFL Graph Search

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The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...

The AIDRES database aims to support the long-term objective of a fully integrated industrial strategy in the EU 27, providing a service to the European Commission and a catalogue for industries to understand the effectiveness, efficiency and cost of potent ...

Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of signaling across different cellular compartments. However, how nonenzymatic PTMs-despite their direct relevance to covalent drug development-impinge on crosscompartment sign ...

Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...

Ribonucleotide reductase (RNR) is an essential enzyme in DNA biogenesis and a target of several chemotherapeutics. Here, we investigate how antileukemic drugs (e.g., clofarabine [CIF]) that target one of the two subunits of RNR, RNR-alpha, affect noncanoni ...

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...

Yi Zhao

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The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor

AIDRES: A database for the decarbonisation of the heavy industry in Europe

Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Clofarabine Commandeers the RNR-alpha-ZRANB3 Nuclear Signaling Axis

Z-REX uncovers a bifurcation in function of Keap1 paralogs