Publications de Giovanni D'Angelo

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To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis-trans axis of the organelle. How such compartment ...

Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus infectivity. Indoors, small exhaled aerosols undergo r ...

SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action ...

Sphingolipids are a fundamental class of molecules that are involved in structural, organizational and signaling properties of eukaryotic membranes. Defects in their production or disposal lead to acquired and inherited human diseases. A growing community ...

Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition. Here, ...

AU Lipid: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly transfer proteins (LTPs) are key players in cellular homeostasis : and regulation, as they coordinate the exchange of lipids between different cellular organelles. Despite their importance, ...

Besides its beneficial effect on weight loss, gastric bypass surgery (GBS) may impact the circulating levels of phospho- and sphingolipids. However, long-term effects have not been explored. To investigate alterations in lipidomic signatures associated wit ...

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

Glycosphingolipids are important components of the plasma membrane where they modulate the activities of membrane proteins including signalling receptors. Glycosphingolipid synthesis relies on competing reactions catalysed by Golgi-resident enzymes during ...

Giovanni D'Angelo and Gioele La Manno present the concept of lipotypes, and suggest that lipid composition is an important regulator of cell fate. ...

The impact of mechanical stimuli on cell organelles is unexplored due to lack of research tools. This study introduces a novel method combining nanodiamond quantum sensing and optical trapping to explore redox metabolism and viscoelastic properties in card ...

Lipids are major cell constituents endowed with astonishing structural diversity. The pathways responsible for the assembly and disposal of different lipid species are energetically demanding, and genes encoding lipid metabolic factors and lipid-related pr ...

Giovanni D'Angelo

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ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Meeting Report – The 2019 FEBS special meeting on sphingolipid biology: sphingolipids in physiology and pathology

Sphingolipids control dermal fibroblast heterogeneity

The conformational plasticity of structurally unrelated lipid transport proteins correlates with their mode of action

Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3

The lipotype hypothesis

ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

Optically Trapped Nano-diamond Quantum Sensors to Explore Viscoelastic Properties and Redox Metabolism of Cells in Cardiac Fibrosis

Sphingolipid metabolism and signaling: embracing diversity

Single cell lipid biology