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Yimon Aye

Cette personne a quitté l’EPFL

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Publications associées (48)

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Where Electrophile Signaling and Covalent Ligand-Target Mining Converge

Yimon Aye

Interests in learning how to engineer most effective covalent ligands, identify novel functional targets, and define precise mechanism-of-action are rapidly growing in both academia and pharmaceutical industries. We here illuminate the establishment of a m ...

2020

Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales

Pierre Alexander Miranda Herrera, Yimon Aye, Romain Hamelin, Yi Zhao, Dalu Chang

Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of signaling across different cellular compartments. However, how nonenzymatic PTMs-despite their direct relevance to covalent drug development-impinge on crosscompartment sign ...

National Academy of Sciences2022

Science's Response to CoVID-19

Yimon Aye

CoVID-19 is a multi-symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists a ...

WILEY-V C H VERLAG GMBH2021

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Yimon Aye, Yi Zhao

Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...

ROYAL SOC CHEMISTRY2020

Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles

Yimon Aye, Xuyu Liu

Revolutionary proteomic strategies have enabled rapid profiling of the cellular targets of electrophilic small molecules. However, precise means to directly interrogate how these individual electrophilic modifications at low occupancy functionally reshape ...

2019

Nuclear RNR-alpha antagonizes cell proliferation by directly inhibiting ZRANB3

Yimon Aye

Since the origins of DNA-based life, the enzyme ribonucleotide reductase (RNR) has spurred proliferation because of its rate-limiting role in de novo deoxynucleoside-triphosphate (dNTP) biosynthesis. Paradoxically, the large subunit, RNR-alpha, of this obl ...

2018

Clofarabine Commandeers the RNR-alpha-ZRANB3 Nuclear Signaling Axis

Yimon Aye, Yi Zhao

Ribonucleotide reductase (RNR) is an essential enzyme in DNA biogenesis and a target of several chemotherapeutics. Here, we investigate how antileukemic drugs (e.g., clofarabine [CIF]) that target one of the two subunits of RNR, RNR-alpha, affect noncanoni ...

CELL PRESS2020

Formaldehyde regulates one-carbon metabolism and epigenetics

Yimon Aye

Recently, Pham et al. used an array of model systems to uncover a role for the enzyme methionine adenosyltransferase (MAT) -1A, which is mainly expressed in liver, in both sensing formaldehyde and regulating transcriptional responses that protect against i ...

Cell Press2024

Let's get biophysical - How to get your favorite protein's digits☆

Yimon Aye

In these days of information overload and high-throughput analysis, it is easy to lose focus on the study of individual proteins. It is our conjecture that such investigations are still crucially important and offer uniquely penetrative insights. We thus p ...

PERGAMON-ELSEVIER SCIENCE LTD2024

Redox Signaling by Reactive Electrophiles and Oxidants

Yimon Aye, Jesse Poganik

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and mul ...

2018

Toward decoding spatiotemporal signaling activities of reactive immunometabolites with precision immuno-chemical biology tools

Yimon Aye, Kuan-Ting Huang

Immune-cell reprogramming driven by mitochondria-derived reactive electrophilic immunometabolites (mt-REMs—e.g., fumarate, itaconate) is an emerging phenomenon of major biomedical importance. Despite their localized production, mt-REMs elicit significantly ...

2024

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Yimon Aye, Jesse Poganik, Alexandra Krina Van Hall-Beauvais, Kuan-Ting Huang, Yi Zhao, Xuyu Liu

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...

eLIFE SCIENCES PUBL LTD2022

Hiding in Plain Sight: The Issue of Hidden Variables

Yimon Aye

Here we discuss "hidden variables", which are typically introduced during an experiment as a consequence of the application of two independent variables together to create a stimulus. With increased sophistication in modern chemical biology tools and relat ...

AMER CHEMICAL SOC2022

An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX

Yimon Aye, Chloé Rogg

Here we provide a personal account of innovation and design principles underpinning a method to interrogate precision electrophile signaling that has come to be known as "REX technologies". This Account is framed in the context of trying to improve methods ...

American Chemical Society2021

Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation

Yimon Aye

A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin, and ...

AMER CHEMICAL SOC2019

Weighing up the Selenocysteome Uncovers New Sec-rets

Yimon Aye, Jesse Poganik

Challenging the paradigm of SECIS-dependent selenoprotein translation, in this issue of Cell Chemical Biology Guo et al. (2018) introduce a new selenoprotein profiling platform with which they identify novel selenoproteins apparently lacking SECIS. With in ...

CELL PRESS2018

Horner-Wadsworth-Emmons olefination for bioconjugation

Yimon Aye

Through site-specific generation of intermediary reactive aldehydes, Horner-Wadsworth-Emmons olefination can now deliver selective functionalization of stable recombinant proteins and monoclonal antibodies, whilst preserving protein integrity. ...

Springernature2024

Leaving their mark: From precision electrophile signaling to covalent ligand evolution

Yimon Aye

AMER CHEMICAL SOC2019

Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization

Kevin Timothy Fridianto, Yimon Aye

Current methods have limited ability in directly quantifying the extent of glutathionylation on specific proteincysteines. In this issue of Cell Chemical Biology, Ahn et al.1 report G-ICAT (glutathione-based isotope-coded affinity tag), aimed at addressing ...

CELL PRESS2023

Editorial overview: From the iceman to modern medicine

Yimon Aye

ELSEVIER SCI LTD2019