Muhammad Umair Anwar

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To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. ...

Muhammad Umair Anwar

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ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains