Publications de Sarah Wehrle | EPFL Graph Search

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Proteins are the basic building blocks necessary for the operation and regulation of virtually all functions in living organisms. Over millions of years, evolution has created a vast repertoire of proteins finely tuned to execute their biological functions ...

The robust computational design of functional proteins has the potential to deeply impact translational research and broaden our understanding of the determinants of protein function and stability. The low success rates of computational design protocols an ...

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

Plant reproduction relies on the highly regulated growth of the pollen tube for sperm delivery. This process is controlled by secreted RALF signaling peptides, which have previously been shown to be perceived by Catharanthus roseus RLK1-like (CrRLK1Ls) mem ...

The humoral responses of Ebola virus (EBOV) survivors mainly target the surface glycoprotein GP, and anti-GP neutralizing antibodies have been associated with protection against EBOV infection. In order to elicit protective neutralizing antibodies through ...

Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, t ...

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

Sarah Wehrle

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Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

Rosetta FunFolDes - A general framework for the computational design of functional proteins

De novo design of protein interactions with learned surface fingerprints

Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Systems and methods for de novo design of protein interactions with learned surface fingerprints

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Design and characterization of near-native Ebola GP vaccine candidates: implications for immunogenicity

De Novo Design of Site-specific Protein Binders Using Surface Fingerprints