Erick Jorge Canales Rodriguez

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In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the larg ...

In this study, we developed a robust inversion algorithm to estimate the Neurite Orientation Dispersion and Density Imaging (NODDI) model. It is based on the Accelerated Microstructure Imaging via Convex Optimization (AMICO) framework. However, in contrast ...

Diffusion MRI (dMRI) of the developing brain can provide valuable insights into the white matter development. However, slice thickness in fetal dMRI is typically high (i.e., 3-5 mm) to freeze the in-plane motion, which reduces the sensitivity of the dMRI s ...

Axon radius is a potential biomarker for brain diseases and a crucial tissue microstructure parameter that determines the speed of action potentials. Diffusion MRI (dMRI) allows non-invasive estimation of axon radius, but accurately estimating the radius o ...

Constrained Spherical Deconvolution (CSD) is a state-of-the-art technique for unraveling complex fiber configurations of white matter from diffusion MRI data. Despite its ability to identify multiple fiber orientations, it faces difficulties in resolving f ...

Schizophrenia may represent a trade-off in the evolution of human-specific ontogenetic mechanisms that guide neurodevelopment. Human Accelerated Regions (HARs) are evolutionary markers functioning as neurodevelopmental transcription enhancers that have bee ...

Introduction: Estimating the risk of manic relapse could help the psychiatrist individually adjust the treatment to the risk. Some authors have attempted to estimate this risk from baseline clinical data. Still, no studies have assessed whether the estimat ...

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

Purpose Biophysical models of diffusion MRI have been developed to characterize microstructure in various tissues, but existing models are not suitable for tissue composed of permeable spherical cells. In this study we introduce Cellular Exchange Imaging ( ...

At the typical spatial resolution of MRI in the human brain, approximately 60–90% of voxels contain multiple fiber populations. Quantifying microstructural properties of distinct fiber populations within a voxel is therefore challenging but necessary. Whil ...

In magnetic resonance imaging, the application of a strong diffusion weighting suppresses the signal contributions from the less diffusion-restricted constituents of the brain's white matter, thus enabling the estimation of the transverse relaxation time T ...

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC Bead ...

Limitations in the accuracy of brain pathways reconstructed by diffusion MRI (dMRI) tractography have received considerable attention. While the technical advances spearheaded by the Human Connectome Project (HCP) led to significant improvements in dMRI da ...

DDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive processing speed (PS). First, following a case-control design (Study ...

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) chara ...

Background: Individuals with bipolar disorder have been reported to have increased white matter hyperintensities (WMH) in fluid-attenuated inversion recovery (FLAIR) magnetic resonance scans. However, it is unknown whether this WMH increase has any impact ...

Erick Jorge Canales Rodriguez

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Age- and gender-related differences in brain tissue microstructure revealed by multi-component T2 relaxometry

Fast and robust estimation of NODDI parameters using non-Gaussian noise models and spatial regularization

Slice Estimation in Diffusion MRI of Neonatal and Fetal Brains in Image and Spherical Harmonics Domains Using Autoencoders

Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology

Spatial Prior Informed Constrained Spherical Deconvolution in Super Resolution Variation

Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

Improved estimation of the risk of manic relapse by combining clinical and brain scan data

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Cellular EXchange Imaging (CEXI): Evaluation of a diffusion model including water exchange in cells using numerical phantoms of permeable spheres

Resolving bundle-specific intra-axonal T2 values within a voxel using diffusion-relaxation tract-based estimation

Axonal T2 estimation using the spherical variance of the strongly diffusion-weighted MRI signal

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Insights from the IronTract challenge: Optimal methods for mapping brain pathways from multi-shell diffusion MRI

Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia

Sulcal Pits as Potential Markers of Early Sex-related Human Brain Differences in Healthy Adults

Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Surface-based morphometry abnormality in schizophrenia and its relation to positive, negative and disorganized syndromes

Impact of Bipolar Disorder Increased White Matter Hyperintensities on White Matter Connectivity

Multimodal microstructure imaging: combining relaxometry and diffusometry to estimate myelin, intracellular, extracellular, and cerebrospinal fluid properties