Publications de Alice Comberlato

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Recent advances in the field of nanomaterials demonstrated how their use for vaccination can drastically improve immune responses, mainly by enhancing delivery and uptake of vaccine components. However, our understanding of the connections between presenta ...

Most vaccines developed today include only the antigens that best stimulate the immune system rather than the entire virus or microbe, which makes vaccine production and use safer and easier, though they lack potency to induce acceptable immunity and long- ...

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent development of protective coating strategies prolonging structural integrity in physiological conditions. For tailored biologic ...

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor binding and cell signaling have emerged recently. Here, we demonstrate the importance of controlled nanospacing of immunostimulatory ...

Phage display is a powerful technique routinely used for the generation of peptide- or protein-based ligands. The success of phage display selections critically depends on the size and structural diversity of the libraries, but the generation of large libr ...

DNA-based nanomaterials are gaining popularity as uniform and programmable bioengineering tools as a result of recent solutions to their weak stability under biological conditions. The DNA nanotechnology platform uniquely allows decoupling of engineering p ...

Alice Comberlato

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DNA-based biomaterials for nanoscale controlled modulation of immune cells

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials

Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity

Strategic Insights into Engineering Parameters Affecting Cell Type-Specific Uptake of DNA-Based Nanomaterials