Stephanie Jocelyne Sungalee

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In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is a ...

Double-strand breaks (DSBs) are the most toxic type of DNA lesions. Cells repair these lesions using either end protection- or end resection-coupled mechanisms. To study DSB repair choice, we present the Color Assay Tracing-Repair (CAT-R) to simultaneously ...

Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...

Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 L ...

Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been charac ...

Stephanie Jocelyne Sungalee

Chattez avec Graph Search

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains

Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes