Publications de Li Tang | EPFL Graph Search

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Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen recognition receptors have been developed as potent adjuvants to optimize the immunogenicity and efficacy of vaccines. Recently discovered cyclic GMP-AMP synthase-stimulator ...

Recent clinical success of systemic cancer immunotherapy has paved the way for the next-generation therapeutics. Nevertheless, cancer immunotherapies, in particular combination therapies, are associated in some cases with severe side effects and low respon ...

The present invention concerns a method for producing polymers suitable as carrier-free delivery system of bioactive molecules, in particular bioactive peptides. The method comprises the polycondensation of one or more different monomers, including monomer ...

Targeting the stimulator of interferon genes (STING) pathway with cyclic dinucleotides (CDNs), the natural STING agonists, is a promising immunotherapeutic strategy for cancer. However, the clinical application of natural CDNs as therapeutics is greatly hi ...

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions ...

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigen ...

Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon1,2. A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1 ...

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades. ...

The present disclosure relates to new agents useful for anti-cancer therapy such as anti-cancer adoptive T-cell transfer (ACT) immunotherapy or immune check-point blockade therapy and related compositions, uses and methods thereof. ...

© 2024 The AuthorsMany cancer immunotherapies rely on robust CD8+ T cells capable of eliminating cancer cells and establishing long-term tumor control. Recent insights into immunometabolism highlight the importance of nutrients and metabolites in T cell ac ...

Our Emerging Investigator Series features exceptional work by early-career researchers working in the field of materials science. ...

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

We would like to take this opportunity to highlight the Outstanding Reviewers for Biomaterials Science in 2019, as selected by the editorial team for their significant contribution to the journal. ...

Li Tang

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Delivery of STING agonists for adjuvanting subunit vaccines

Synthetic 3D scaffolds for cancer immunotherapy

Polymer or polycondensate based on peptide, linker and optionally other monomers and method for preparing the same

Harboring CAR-T cells using an injectable scaffold to treat solid tumors

Il-10 Expressing Cd19 Car-t Cells Induce Complete Remission and Improve Long-term Protection in Relapsed or Refractory B-cell Hematological Malignancies

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Highly effective adoptive t cell therapy

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

Il-21 fusion proteins useful as enhancers of anti-cancer immunotherapies

A new paradigm for cancer immunotherapy: Orchestrating type 1 and type 2 immunity for curative response

A Magnetic Nanovaccine Enhances Cancer Immunotherapy

Mimicking the TCR immune synapse for improved CAR-T cell function

Il10/fc fusion proteins useful as enhancers of immunotherapies

Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission

Metabolic immunoengineering approaches to enhance CD8+ T cell-based cancer immunotherapy

Materials Horizons Emerging Investigator Series: Li Tang, ecole polytechnique federale de Lausanne (EPFL), Switzerland

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

6-diazo-5-oxo-l-norleucine prodrugs

Outstanding Reviewers for Biomaterials Science in 2019