Publications de Valeria Cagno | EPFL Graph Search

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Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

Heparin has been known to be a broad-spectrum inhibitor of viral infection for almost 70 years, and it has been used as a medication for almost 90 years due to its anticoagulant effect. This nontoxic biocompatible polymer efficiently binds to many types of ...

Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...

Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and character ...

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or ba ...

Because of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) ...

The invention relates to virucidal compositions comprising a sialic acid (SA) moiety, pharmaceutical compositions and disinfection and/or sterilization compositions comprising thereof and uses thereof in disinfection and/or sterilization methods and in tre ...

The invention relates to virucidal nanoparticles comprising a trisaccharide moiety and use thereof against influenza virus. ...

The invention relates to virucidal metallic nanoparticles, virucidal compositions comprising thereof and uses thereof in treatment and/or prevention of viral infections, for sterilizations and for disinfections. ...

Valeria Cagno

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Modified cyclodextrins as broad-spectrum antivirals

Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Inhibitors of acyl protein thioesterases against microbial infections

Virus adaptation to heparan sulfate comes with capsid stability tradeoff

Virucidal compositions and use thereof

Virucidal nanoparticles and use thereof against influenza virus

Virucidal metallic nanoparticles and uses thereof