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Allison Marie Burns

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Publications associées (4)

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The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Johannes Gräff, Jose Vicente Sanchez Mut, Giulia Santoni, Allison Marie Burns

Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...

2022

Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

Johannes Gräff, Allison Marie Burns

Multiple studies have found that increasing histone acetylation by means of histone deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode of action is not fully understood. In particular, it is uncle ...

2020

Epigenetic memory aids: Synaptic and molecular effects of HDAC inhibition that support memory formation

Allison Marie Burns

Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...

EPFL2022

A thalamo-amygdalar circuit underlying the extinction of remote fear memories

Maria del Carmen Sandi Perez, Johannes Gräff, Simone Astori, Bianca Ambrogina Silva, Giulia Santoni, Allison Marie Burns

Silva et al. reveal distinct circuits for the extinction of remote fear memories, with the thalamic nucleus reuniens and its outputs to the basolateral amygdala taking center stage. Fear and trauma generate some of the longest-lived memories. Despite the c ...

2021