Publications de Fabian Sesterhenn

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The robust computational design of functional proteins has the potential to deeply impact translational research and broaden our understanding of the determinants of protein function and stability. The low success rates of computational design protocols an ...

Proteins have evolved over millions of years to carry out the vast majority of biological functions that are fundamental to life. Their three-dimensional structures and functions have been in the focus of biomedical research for many decades, and substanti ...

De novo protein design enables the exploration of novel sequences and structures absent from the natural protein universe. De novo design also stands as a stringent test for our understanding of the underlying physical principles of protein folding and may ...

BackgroundLarge-scale datasets of protein structures and sequences are becoming ubiquitous in many domains of biological research. Experimental approaches and computational modelling methods are generating biological data at an unprecedented rate. The deta ...

Diverse antibody repertoires spanning multiple lymphoid organs (i.e., bone marrow, spleen, lymph nodes) form the foundation of protective humoral immunity. Changes in their composition across lymphoid organs are a consequence of B-cell selection and migrat ...

Vaccines have been one of the most successful interventions in global health. However, traditional vaccine development has proven insufficient to deal with pathogens that elude the immune system through highly variable and non-functional epitopes. Emerging ...

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remain ...

De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to the difficulty of transplanting structurally complex functional sites to available protein structur ...

Polypeptides useful in the preparation of vaccine compositions against RSV are provided. Also disclosed are methods of enhancing subdominant antibody responses in a subject. ...

Fabian Sesterhenn

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Rosetta FunFolDes - A general framework for the computational design of functional proteins

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

A generic framework for hierarchical de novo protein design

rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics

The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

Structure-based immunogen design - leading the way to the new age of precision vaccines

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Bottom-up de novo design of functional proteins with complex structural features

Driving Immune Responses with Synthetic Proteins - Development of De Novo Designed Immunogens to Elicit Respiratory Syncytial Virus Neutralizing Antibodies

Immunogen

Immunogen