Elisa Oricchio

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Publications associées (29)

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Cathepsin inhibitors and uses thereof

Luc Reymond, Elisa Oricchio, Elena Battistello

The present invention relates to new agents and compositions thereof useful for anti-cancer and immunological disorder therapy and uses thereof. The invention further relates to a method of identifying agents useful in the potentiation of immunotherapy, in ...

2021

Generation and characterization of a single-chain anti-EphA2 antibody

Elisa Oricchio

Recombinant antibody phage library technology provides multiple advantages, including that human antibodies can be generated against proteins that are highly conserved between species. We used this technology to isolate and characterize an anti-EphA2 singl ...

2014

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Elisa Oricchio, Mohammad Sadegh Saghafinia, Daniele Tavernari, Elena Battistello, Stephanie Jocelyne Sungalee, Franck Claude Raynaud

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017

Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes

Elisa Oricchio, Daniele Tavernari, Stephanie Jocelyne Sungalee

Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been charac ...

Nature Research2021

Progress against follicular lymphoma

Elisa Oricchio

To share the recent progress in research and new therapies against follicular lymphoma and highlight the exciting opportunities to improve the treatment of follicular lymphoma. ...

Lippincott, Williams & Wilkins2013

Chromatin organization in red triangles

Elisa Oricchio

This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs). ...

NATURE PORTFOLIO2023

Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells

Elisa Oricchio

The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-defi ...

Cell Press2016

Novel cathepsin inhibitors

Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Aaron Simone Petruzzella

The present invention relates to a cathepsin inhibitor comprising or consisting of Formula (I) (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) wherein (X1) is an amino acid selected from K, L, F and M; (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S ...

2023

De Novo Design of Site-specific Protein Binders Using Surface Fingerprints

Elisa Oricchio, Pablo Gainza Cirauqui, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Zander Harteveld, Andreas Scheck, Sarah Wehrle, Alexandra Krina Van Hall-Beauvais, Freyr Sverrisson, Aaron Simone Petruzzella

WILEY2021