Publications de Mehmet Ugur Girgin

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Previous attempts to recapitulate embryogenesis in a developmentally relevant context started with aggregates composed of a few thousand ESCs, termed embryoid bodies (EB), that upon induction of differentiation reveal a surprising level of autonomous cell ...

When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and patterning along the three major body axes. However, these structures, called gastru ...

Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model system in recapitulating key steps of in-vivo morphogenesis. Current approaches to constructing such ...

The difficulty of studying post-implantation development in mammals has sparked a flurry of activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent stem cells. Previous approaches to derive embryoids either lack the phys ...

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

The emergence of multiple axes is an essential element in the establishment of the mammalian body plan. This process takes place shortly after implantation of the embryo within the uterus and relies on the activity of gene regulatory networks that coordina ...

As the field of tissue engineering develops, methods for screening combinations of signals for their effects on stem cell behavior are needed. We introduce a microgel-based screening platform for testing combinations of in situ-generated proteins on stem c ...

This imagej macro analyses the reporter intensity activity and expression domain in EPI aggregates and Gastruloids. ...

Mehmet Ugur Girgin

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In vitro modeling of early mouse development

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues

Mammary epithelial morphogenesis in 3D combinatorial microenvironments

Bioengineered embryoids mimic post-implantation development in vitro

Capturing Cardiogenesis in Gastruloids

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

High-throughput stem cell-based phenotypic screening through microniches

Measuring reporter activity domain in EPI aggregates and Gastruloids.ijm