Evaristo Jose Planet Letschert

Cette personne a quitté l’EPFL

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Publications associées (29)

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Genetic features and genomic targets of human KRAB-zinc finger proteins

Jacques Fellay, Didier Trono, Priscilla Turelli, Christian Axel Wandall Thorball, Julien Léonard Duc, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Alexandre Coudray, Michaël Imbeault, Cyril David Son-Tuyên Pulver, Romain Forey, Jonas Caspar De Tribolet-Hardy

Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by ...

2023

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Didier Trono, Laurence Gouzi Abrami, Julien Léonard Duc, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Alexandre Coudray, Laia Simo Riudalbas, Sagane Dind

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

Nature Research2022

ZNF445 is a primary regulator of genomic imprinting

Didier Trono, Priscilla Turelli, Christian Axel Wandall Thorball, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Michaël Imbeault, Andrea Coluccio

Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertil ...

2019

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Filipe Amândio Brandão Sanches Vong Martins, Charlène Mireille Raymonde Raclot, Olga Marie Louise Rosspopoff, Cyril David Son-Tuyên Pulver, Romain Forey

ZNF93 is a primate-restricted Krüppel-associated box zinc finger protein responsible for repressing 20- to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B—a mutagenic enzyme linked to tumorigenes ...

Proceedings of the National Academy of Sciences2025

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

Didier Trono, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to immune ...

2023

Transpochimeric gene trancripts (tcgts) as cancer biomarkers

Didier Trono, Julien Léonard Duc, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

The invention relates to methods for detecting or predicting the likelihood of a cancer in a subject as well as to compositions, pharmaceutical compositions and methods of treatment of cancer. ...

2020

Evaristo Jose Planet Letschert

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Genetic features and genomic targets of human KRAB-zinc finger proteins

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

ZNF445 is a primary regulator of genomic imprinting

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

Transpochimeric gene trancripts (tcgts) as cancer biomarkers

The interplay between regulatory variants, transposable elements and gene expression in the context of colorectal cancer

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Transposable element-driven transcripts as new cancer biomarkers