Evaristo Jose Planet Letschert

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Publications associées (29)

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Didier Trono, Priscilla Turelli, Evaristo Jose Planet Letschert

BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expression and ALS. C ...

2018

Transposable element-driven transcripts as new cancer biomarkers

Didier Trono, Julien Léonard Duc, Julien Duc, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

MARY ANN LIEBERT, INC2018

Polyphenic trait promotes liver cancer in a model of epigenetic instability

Didier Trono, Sandra Eloise Kjeldsen, Marco Cassano, Alessandra Piersigilli, Suk Min Jang, Evaristo Jose Planet Letschert

Hepatocellular carcinoma (HCC) represents the fifth most common form of cancer worldwide and carries a high mortality rate due to lack of effective treatment. Males are eight times more likely to develop HCC than females, an effect largely driven by sex ho ...

Wiley-Blackwell2017

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Sonia Verp, Julien Léonard Duc, Andrea Coluccio, Alberto De Iaco, Evaristo Jose Planet Letschert

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

MicroRNA Profile in CD8+T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

Evaristo Jose Planet Letschert

Background The relationship between host microRNAs (miRNA), viral control and immune response has not yet been elucidated in the field of HIV. The aim of this study was to assess the differential miRNA profile in CD8+ T-cells between HIV-infected individua ...

Public Library of Science2016

Molecular Criteria for Defining the Naive Human Pluripotent State

Didier Trono, Julien Léonard Duc, Marc Samuel Friedli, Alexandra Iouranova, Michaël Imbeault, Evaristo Jose Planet Letschert, Julien Paul André Pontis, Haoyi Wang

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...

Cell Press2016

Stratification and therapeutic potential of PML in metastatic breast cancer

Evaristo Jose Planet Letschert

Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel tar ...

Nature Publishing Group2016

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Didier Trono, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert

The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...

Cold Spring Harbor Lab Press, Publications Dept2015

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Didier Trono, Priscilla Turelli, Bastien Mangeat, Helen Mary Rowe, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Benjamin Rauwel, Carmen Maria Unzu Ezquerro, Evaristo Jose Planet Letschert

Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control is maint ...

Cold Spring Harbor Lab Press, Publications Dept2014

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