Duncan-Bruce Sutherland

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Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helmin ...

Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses ...

Immunoglobulin A (IgA), the most abundantly secreted antibody isotype in mammals, not only provides direct immune protection to neonates via maternal milk but also helps program the infant immune system by regulating the microbiota. IgA continues to mainta ...

The invention relates to a food supplement comprising or consisting of Archaebacteria, and particularly methanogenic Archaebacteria, to be used as a probiotic adjunct for animal feed. The supplement can be provided to e.g. farmed animals in addition to sta ...

Eosinophils are found in abundance in the gut. In this issue of Immunity, Chu et al. (2014) report that eosinophil-deficient mice have impaired intestinal immunoglobulin A production, accompanied by a disrupted mucosal layer and alterations in microbiota d ...

The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dy ...

The present invention generally relates to the field of intestinal health, disorders associated with aberrant microbiota and/or archaea-deficiency, and early-life immune system development. The present invention more specifically relates to M. smithii and ...

The recombinant antibodies RB714, RB715, RB716, RB717 and RB718 detect by ELISA the M. smithi histone HMtA protein fused to a GST. ...

Duncan-Bruce Sutherland

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Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

Fostering of advanced mutualism with gut microbiota by Immunoglobulin A

Archaebacteria in bioactive animal feed, method of making the composition and methods employing the composition

Gut Reactions: Eosinophils Add another String to Their Bow

Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions

Methanobrevibacter smithii ( m. smithii) for use as a biomarker and in the diagnosis and the treatment of disorders associated with aberrant microbiota and/or archaea-deficiency

RB714, RB715, RB716, RB717 and RB718 antibodies recognize the histone HMtA protein from Methanobrevibacter smithii by ELISA