Johannes Gräff

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Publications associées (31)

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Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Johannes Gräff, Liliane Glauser, Lucie Pauline Dixsaut, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

American Association for the Advancement of Science2018

A thalamo-amygdalar circuit underlying the extinction of remote fear memories

Maria del Carmen Sandi Perez, Johannes Gräff, Simone Astori, Bianca Ambrogina Silva, Giulia Santoni, Allison Marie Burns

Silva et al. reveal distinct circuits for the extinction of remote fear memories, with the thalamic nucleus reuniens and its outputs to the basolateral amygdala taking center stage. Fear and trauma generate some of the longest-lived memories. Despite the c ...

2021

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Johannes Gräff, Jose Vicente Sanchez Mut

Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. ...

Nature Research2017

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Johannes Gräff, Jose Vicente Sanchez Mut, Liliane Glauser

Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...

2020

From cellular to fear memory: An epigenetic toolbox to remember

Johannes Gräff, Davide Martino Coda

Throughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last for decades, but ...

Current Biology Ltd2023

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Myriam Schioppa, Maria del Carmen Sandi Perez, Johannes Gräff, Marion Leleu, Liliane Glauser, Simone Astori, Giulia Santoni, Isabella Tarulli

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in t ...

American Association for the Advancement of Science2024

On the resilience of remote traumatic memories against exposure therapy-mediated attenuation

Johannes Gräff

How to attenuate traumatic memories has long been the focus of intensive research efforts, as traumatic memories are extremely persistent and heavily impinge on the quality of life. Despite the fact that traumatic memories are often not readily amenable to ...

2014

Epigenetic regulation of cognitive decline in Alzheimer's disease

Johannes Gräff

ELSEVIER SCIENCE BV2019

Face your fears: attenuating remote fear memories by reconsolidation-updating

Johannes Gräff, Bianca Ambrogina Silva

Traumatic events generate some of the most enduring memories, yet little is known about how long-lasting fear memories can be attenuated. In this review, we collect the surprisingly sparse evidence on remote fear memory attenuation from both animal and hum ...

ELSEVIER SCIENCE LONDON2023

Methods of diagnosis alzheimer's disease

Johannes Gräff, Jose Vicente Sanchez Mut

A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variati ...

2018

ABBA+BraiAn, an integrated suite for whole-brain mapping, reveals brain-wide differences in immediate-early genes induction upon learning

Johannes Gräff, Arne Seitz, Nicolas René Chiaruttini

Elsevier BV2025