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Johannes Gräff

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Publications associées (34)

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Graham Knott, Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Elias Georges Gebara, Wei Tang, Alexandre Claude Gustave Bacq, Johannes Gräff, Catherine Maclachlan, Jose Vicente Sanchez Mut, Bianca Ambrogina Silva, Simone Astori

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. ...

2020

Methods of diagnosis alzheimer's disease

Johannes Gräff, Jose Vicente Sanchez Mut

A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variati ...

2018

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

Liliane Glauser, Bernard Schneider, Johannes Gräff, Lucie Pauline Dixsaut, Jose Vicente Sanchez Mut, Bianca Ambrogina Silva

2018

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Liliane Glauser, Victoire Gorden, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Johannes Gräff, Lucie Pauline Dixsaut, Siegfried Resch

American Association for the Advancement of Science2018

The mysteries of remote memory

Johannes Gräff, Zimbul Albo

Long-lasting memories form the basis of our identity as individuals and lie central in shaping future behaviours that guide survival. Surprisingly, however, our current knowledge of how such memories are stored in the brain and retrieved, as well as the dy ...

2018

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex

Johannes Gräff, Jose Vicente Sanchez Mut

The brain's neocortex is anatomically organized into grey and white matter, which are mainly composed by neuronal and glial cells, respectively. The neocortex can be further divided in different Brodmann areas according to their cytoarchitectural organizat ...

Wiley-Blackwell2017

Rewrite or overwrite: identifying neuromolecular circuits of remote fear memory attenuation

Johannes Gräff

Springer Wien2017

A cortico-thalamic-hippocampal circuit for remote fear memory attenuation

Ralf Schneggenburger, Johannes Gräff, Michael Kintscher, Bianca Ambrogina Silva

Springer Wien2017

FORMINg a link between PTSD and AD

Johannes Gräff

Epidemiological evidence suggests that people suffering from post-traumatic stress disorder have a higher risk for developing Alzheimer's disease. The underlying mechanisms, however, remained thus far unexplored. In this issue of The EMBO Journal, Agis-Bal ...

Nature Publishing Group2017

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Johannes Gräff, Jose Vicente Sanchez Mut

Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. ...

Nature Research2017

Cortical neurons gradually attain a post-mitotic state

Johannes Gräff

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

Epigenetic Alterations in Alzheimer's Disease

Johannes Gräff, Jose Vicente Sanchez Mut

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses asymptomatically during decades before being belatedly diagnosed when therapeutic strategies have become unviable. Although several genetic alterations have been as ...

Frontiers Research Foundation2015

Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway

Johannes Gräff, Jun Wang

Repeated stress has been suggested to underlie learning and memory deficits via the basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA inputs to the hippocampus and their molecular repercussions are not well underst ...

National Academy of Sciences2015

On the resilience of remote traumatic memories against exposure therapy-mediated attenuation

Johannes Gräff

How to attenuate traumatic memories has long been the focus of intensive research efforts, as traumatic memories are extremely persistent and heavily impinge on the quality of life. Despite the fact that traumatic memories are often not readily amenable to ...

2014

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