Julien Robert Rémi Faget

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The immune checkpoint blockade-based immunotherapies are revolutionizing cancer management. Tumor-associated neutrophils (TANs) were recently highlighted to have a pivotal role in modulating the tumor microenvironment and the antitumor immune response. How ...

Background Activin-A, a transforming growth factor beta family member, is secreted by many cancer types and is often associated with poor disease prognosis. Previous studies have shown that Activin-A expression can promote cancer progression and reduce the ...

OBJECTIVES: Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Approaches to enhance patient immunity against MPM have been tested but shown variable results. Previously, we have demonstrated interesting vascular modul ...

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

Julien Robert Rémi Faget

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Neutrophils in the era of immune checkpoint blockade

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Low dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of malignant pleural mesothelioma

Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

Durable and controlled depletion of neutrophils in mice