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Hatice Altug

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Publications associées (123)

Self-assembly of nanostructured glass metasurfaces via templated fluid instabilities

Hatice Altug, Dang Tùng Nguyen, Fabien Sorin, Filiz Yesilköy, Alexis Gérald Page, Wei Yan, Arthur Le Bris, Yunpeng Qu, Louis Marie Philippe Martin-Monier, Kuan-Ting Ho

Modern devices require the tuning of the size, shape and spatial arrangement of nano-objects and their assemblies with nanometre-scale precision, over large-area and sometimes soft substrates. Such stringent requirements are beyond the reach of conventiona ...

Nature Publishing Group2019

Metasurface-Based Molecular Biosensing Aided by Artificial Intelligence

Hatice Altug, Andreas Tittl, Aurélian Michel John-Herpin, Aleksandrs Leitis, Eduardo Romero Arvelo

Molecular spectroscopy provides unique information on the internal structure of biological materials by detecting the characteristic vibrational signatures of their constituent chemical bonds at infrared frequencies. Nanophotonic antennas and metasurfaces ...

Wiley-VCH Verlag GmbH2019

Accessible Superchiral Near-Fields Driven by Tailored Electric and Magnetic Resonances in All-Dielectric Nanostructures

Hatice Altug, Andreas Tittl, Yasaman Jahani, Kosmas Tsakmakidis, Ershad Mohammadi

Detection and differentiation of enantiomers in small quantities are crucially important in many scientific fields, including biology, chemistry, and pharmacy. Chiral molecules manifest their handedness in their interaction with the chiral state of light ( ...

AMER CHEMICAL SOC2019

All-dielectric Metasurfaces for Infrared Absorption Spectroscopy Applications

Hatice Altug, Filiz Yesilköy, Andreas Tittl, Aleksandrs Leitis, Mingkai Liu

We present a nanophotonic method capable of detecting mid-infrared molecular fingerprints without the need for spectrometry, frequency scanning, or moving mechanical parts. We leverage dielectric metasurfaces featuring ultra-sharp resonances each tuned to ...

IEEE2019

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Metasurface‐based molecular biosensing aided by artificial intelligence

Hatice Altug, Andreas Tittl, Aurélian Michel John-Herpin, Aleksandrs Leitis, Eduardo Romero Arvelo

2019

Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening

Sandro Carrara, Hatice Altug, Maria Soler Aznar, Tugba Kilic

The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening met ...

2018

Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...

2018

Quantifying the Limits of Detection of Surface-Enhanced Infrared Spectroscopy with Grating Order-Coupled Nanogap Antennas

Hatice Altug, Andreas Tittl, Aurélian Michel John-Herpin

Infrared spectroscopy is widely used for biomolecular studies, but struggles when investigating minute quantities of analytes due to the mismatch between vibrational cross sections and IR wavelengths. It is therefore beneficial to enhance absorption signal ...

2018

High-Contrast Infrared Absorption Spectroscopy via Mass-Produced Coaxial Zero-Mode Resonators with Sub-10 nm Gaps

Hatice Altug, Aurélian Michel John-Herpin, Sunghwan Kim

We present a wafer-scale array of resonant coaxial nanoapertures as a practical platform for surface-enhanced infrared absorption spectroscopy (SEIRA). Coaxial nanoapertures with sub-10 nm gaps are fabricated via photolithography, atomic layer deposition o ...

American Chemical Society (ACS)2018

Imaging-based molecular barcoding with pixelated dielectric metasurfaces

Hatice Altug, Filiz Yesilköy, Andreas Tittl, Aleksandrs Leitis, Mingkai Liu

Metasurfaces provide opportunities for wavefront control, flat optics, and subwavelength light focusing. We developed an imaging-based nanophotonic method for detecting mid-infrared molecular fingerprints and implemented it for the chemical identification ...

American Association for the Advancement of Science2018

Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces

Hilal Lashuel, Nadine Aït Bouziad, Hatice Altug, Odeta Limaj, Daniel Rodrigo Lopez, Christopher David Kelly, Andreas Tittl, Aurélian Michel John-Herpin

A multitude of biological processes are enabled by complex interactions between lipid membranes and proteins. To understand such dynamic processes, it is crucial to differentiate the constituent biomolecular species and track their individual time evolutio ...

Nature Research2018

Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar

Single-cell analysis of cytokine secretion is essential to understand the heterogeneity of cellular functionalities and develop novel therapies for multiple diseases. Unraveling the dynamic secretion process at single-cell resolution reveals the real-time ...

2018

Nanophotonic Platforms for Enhanced Chiral Sensing

Hatice Altug, Kosmas Tsakmakidis, Ershad Mohammadi

Chirality plays an essential role in life, providing unique functionalities to a wide range of biomolecules, chemicals, and drugs, which makes chiral sensing and analysis critically important. The wider application of chiral sensing continues to be constra ...

2018

Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasm ...

2018

Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar, Aurélian Michel John-Herpin

The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity and kinetics of a T cell receptor (TCR) binding to the peptide-major ...

AMER CHEMICAL SOC2018

Self-Similar Multiresonant Nanoantenna Arrays for Sensing from Near- to Mid-Infrared

Hatice Altug, Odeta Limaj, Daniel Rodrigo Lopez, Andreas Tittl, Aurélian Michel John-Herpin

Tailoring nanoscale light concentration and electromagnetic near-field enhancement over a broad spectral range is crucial for many photonics applications such as infrared spectroscopy, photodetection, and light harvesting. So far, broadband light enhanceme ...

2018

Real-time in-situ secondary structure analysis of protein monolayer with mid-infrared plasmonic nanoantennas

Hilal Lashuel, Hatice Altug, Dordaneh Etezadi

2018

Nanoimaging and Control of Molecular Vibrations through Electromagnetically Induced Scattering Reaching the Strong Coupling Regime

Hatice Altug, Dordaneh Etezadi

2018

Performance metrics and enabling technologies for nanoplasmonic biosensors

Hatice Altug

Nanoplasmonic structures can tightly confine light onto a material's surface to probe biomolecular interactions not easily accessed by other sensing techniques. New and exciting developments in nanofabrication processes, nano-optical trapping, graphene dev ...

Nature Research2018

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