Publications de Nikolaus Wenger

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The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with Spinal Cord Injury (SCI) and Parkinson disease. Stimulation parameters are tuned manually and remain constant during motor execution which is suboptimal ...

Epidural electrical stimulation (EES) showed promises to improve standing and walking after neurological disorders. To date, EES has been delivered continuously, although time-dependent stimulations would likely be more efficient to activate specific subse ...

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

Nikolaus Wenger

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System for selective spatiotemporal stimulation of the spinal cord

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Neuroprosthetic system to restore locomotion after neuromotor disorder

System for selective spatiotemporal stimulation of the spinal cord

A real-time platform for studying the modulatory capacity of epidural stimulation after spinal cord injury

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment