Mario Leonardo Squadrito

Cette personne a quitté l’EPFL

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Publications associées (29)

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Guidance molecule SEMA3A restricts tumor growth by differentially regulating the proliferation of tumor-associated macrophages

Michele De Palma, Mario Leonardo Squadrito

Accumulation of tumor-associated macrophages (TAM) correlates with malignant progression, immune suppression and poor prognosis. In this study, we defined a critical role for the cell-surface guidance molecule SEMA3A in differential proliferative control o ...

American Association for Cancer Research2016

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Michele De Palma, Mario Leonardo Squadrito, Chiara Cianciaruso, Esra Güç, Ioanna Keklikoglou, Alan Nicolas Thierry Guichard

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can ...

2019

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

Michele De Palma, Mario Leonardo Squadrito, Damya Laoui

Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that ...

2011

A niche role for periostin and macrophages in glioblastoma

Michele De Palma, Mario Leonardo Squadrito

Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances gl ...

Nature Publishing Group2015

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

Michele De Palma, Mario Leonardo Squadrito

The role of semaphorins in tumor progression is still poorly understood. In this study, we aimed at elucidating the regulatory role of semaphorin 3A (SEMA3A) in primary tumor growth and metastatic dissemination. ...

2011

Engineered antigen presenting cells and uses thereof

Michele De Palma, Mario Leonardo Squadrito

The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to enhance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to ve ...

2017

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Matthias Lütolf, Michele De Palma, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Nikolche Gjorevski, Alan Nicolas Thierry Guichard

Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential respon ...

2020

DICERing macrophages for reprogramming TAMs

Michele De Palma, Mario Leonardo Squadrito

Landes Bioscience2016

Micromanaging restenosis by therapeutic inhibition of miR-92a

Michele De Palma, Mario Leonardo Squadrito

This editorial refers to 'Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury' by J.-M. Daniel et al., pp. 564-572, this issue. ...

Oxford Univ Press2014