Publications de Sandrine Stutzmann

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Type IV pili are dynamic cell surface appendages found throughout the bacteria. The ability of these structures to undergo repetitive cycles of extension and retraction underpins their crucial roles in adhesion, motility and natural competence for transfor ...

While the major virulence factors for Vibrio cholerae, the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals are re ...

Vibrio cholerae, which causes the diarrheal disease cholera, is a species of bacteria commonlyfound in aquatic habitats. Within such environments, the bacterium must defend itselfagainst predatory protozoan grazers. Amoebae are prominent grazers, withAcant ...

Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...

The human pathogen Vibrio cholerae serves as a model organism for many important processes ranging from pathogenesis to natural transformation, which has been extensively studied in this bacterium. Previous work has deciphered important regulatory circuits ...

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

Natural competence for transformation is a primary mode of horizontal gene transfer. Competent bacteria are able to absorb free DNA from their surroundings and exchange this DNA against pieces of their own genome when sufficiently homologous. However, the ...

Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. The West African–South American (WASA) lineage of V. cholerae, responsible for the 1991–2001 Latin American cholera e ...

Seventh pandemic Vibrio cholerae strains contain two pathogenicity islands that encode the DNA defense modules DdmABC and DdmDE. Here we use cryogenic electron microscopy to reveal the mechanistic basis for plasmid defense by DdmDE. A structure of the DdmD ...

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

Sandrine Stutzmann

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The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase

Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Comparison of chitin‐induced natural transformation in pandemic Vibrio cholerae O1 El Tor strains

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems

Molecular mechanism of plasmid elimination by the DdmDE defense system

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012