Sebastian Martin Waszak

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Publications associées (29)

Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data

Nouria Hernandez, Bart Deplancke, Alisa Yurovsky, Sunil Kumar Raghav, Sebastian Martin Waszak

Motivation: High-throughput sequencing technologies enable the genome-wide analysis of the impact of genetic variation on molecular phenotypes at unprecedented resolution. However, although powerful, these technologies can also introduce unexpected artifac ...

Oxford University Press2014

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Sebastian Martin Waszak

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the oppos ...

Cell Press2014

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Gilles Udin, Didier Trono, Andrea Corsinotti, Bart Deplancke, Sunil Kumar Raghav, Sebastian Martin Waszak, Petra Catalina Schwalie

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiat ...

Elife Sciences Publications Ltd2014

A systems approach to elucidate the genetic architecture of molecular phenotypes

Sebastian Martin Waszak

A growing body of evidence suggests that changes in gene regulatory DNA are the major genetic determinants of variation in complex phenotypes; however, the underlying genes as well as cascades of intermediate molecular events remain in most cases elusive. ...

EPFL2014

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Jovan Simicevic, Carine Delattre-Gubelmann, Jean-Daniel Feuz, Antonina Iagovitina, Bart Deplancke, Alina Isakova, Sunil Kumar Raghav, Sebastian Martin Waszak

The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expression b ...

Nature / European Molecular Biology Organization2013

Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

David Hacker, Gilles Udin, Julien Bryois, Nouria Hernandez, Bart Deplancke, Alisa Yurovsky, Sunil Kumar Raghav, Sarah Thurnheer, Sebastian Martin Waszak

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regu ...

American Association for the Advancement of Science2013

Rounding Up Natural Gene Expression Variation during Development

Bart Deplancke, Sebastian Martin Waszak

Molecular insights into the genetic control of development have been mainly derived from single gene mutant studies. Francesconi and Lehner (2013) report now in Nature a genome-wide map of natural sequence variants that affect the temporal expression dynam ...

Cell Press - Elsevier2013

Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster

Bart Deplancke, Andreas Massouras, Monica Albarca Aguilera, Sebastian Martin Waszak, Jeffrey David Jensen

Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here ...

Public Library of Science2012

Personal receptor repertoires: olfaction as a model

Sebastian Martin Waszak

Background: Information on nucleotide diversity along completely sequenced human genomes has increased tremendously over the last few years. This makes it possible to reassess the diversity status of distinct receptor proteins in different human individual ...

BioMed Central2012

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