Publications de Robert Meissner

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This communication presents a novel experi- mental model for Alzheimer studies, where connected pri- mary neurons were set into subtend, co-pathological states. Cortical neurons were cultured in two separated cell com- partments in a microfluidic device. A ...

We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell cont ...

The impedance of biological material changes with frequency, a phenomenon that has been discovered more than 100 years ago. It is due to the fact that the cell membrane acts as a capacitor which filters out currents at low frequency and lets them pass at h ...

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

Neuronal cell culture models in vitro are often restricted to 2D surfaces. Engineering the complexity of the neuronal microenvironment in microfluidic systems can help to generate more tissue like cultures. We have developed a new neuronal cell culturing s ...

We present an electrical impedance based biosensor on a microfluidic cell culture platform that enables label-free and re- al-time investigation of drug toxicity-induced effects on hepatocytes. The temporal evolution of the impedance at different frequenci ...

We present a novel study on label-free recognition and distinction of drug resistant breast cancer cells (MCF-7 DOX) from their parental cells (MCF-7 WT) via impedimetric measurements. Drug resistant cells exhibited significant differences in their dielect ...

We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each ‘sub-sensor’ po ...

Ca2+ plays a crucial role in cell communication. For example, periodical changes in Ca2+ concentration act as cell sig- nals. Intracellular Ca2+ signals have been measured by Ca2+ sensitive fluorescent dye [1]. In this study, extracellular Ca2+ variation w ...

The invention relates to devices and systems for use in the slicing, separation and possible disposal of slices of a sample, such as a bodily tissue sample. The invention relates to a multi-blade chopper and a guide track comprising knobs along its surface ...

Robert Meissner

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Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

Impedance spectroscopy for in vitro toxicology

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Neurite guidance through 3D hydrogel layers in a microfluidic environment

Continuous and label-free toxicity screening of human hepatocytes on chip reveals frequency-dependant impedance profiles

Label-Free Recognition of Drug Resistance via Impedimetric Screening of Breast Cancer Cells

A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

A Ca2+ ion selective electrode biosensor in microfluidics to monitor hepatocyte’s activities

Device for high- throughput sample slicing and characterization