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Daniel Keller

Cette personne a quitté l’EPFL

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Publications associées (36)

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An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse

Henry Markram, Felix Schürmann, Ralf Schneggenburger, Daniel Keller, Olexiy Kochubey, Yunyun Han

The spatial arrangement of Ca2+ channels and vesicles remains unknown for most CNS synapses, despite of the crucial importance of this geometrical parameter for the Ca2+ control of transmitter release. At a large model synapse, the calyx of Held, transmitt ...

Public Library Science2015

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan, Corrado Cali

Although efficient compared to computers, the human brain utilizes energy at 10-fold the rate of other organs by mass. How the brain is supplied with sufficient on-demand energy to support its activity in the absence of neuronal storage capacity remains un ...

2018

A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex

Henry Markram, Felix Schürmann, Daniel Keller, Olivier Burri, Romain Guiet, Julie Meystre

Obtaining a catalog of cell types is a fundamental building block for understanding the brain. The ideal classification of cell-types is based on the profile of molecules expressed by a cell, in particular, the profile of genes expressed. One strategy is, ...

2019

Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis, Juan José García Cantero

Ultraliser is a neuroscience-specific software framework capable of creating accurate and biologically realistic 3D models of complex neuroscientific structures at intracellular (e.g. mitochondria and endoplasmic reticula), cellular (e.g. neurons and glia) ...

2023

Network-timing-dependent plasticity

Henry Markram, Eilif Benjamin Muller, Daniel Keller, Vincent Delattre

Bursts of activity in networks of neurons are thought to convey salient information and drive synaptic plasticity. Here we report that network bursts also exert a profound effect on Spike-Timing-Dependent Plasticity (STDP). In acute slices of juvenile rat ...

2015

A Cell Atlas for the Mouse Brain

Henry Markram, Daniel Keller, Marc-Oliver Gewaltig

Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. ...

2018

An Alien Divalent Ion Reveals a Major Role for Ca2+ Buffering in Controlling Slow Transmitter Release

Ralf Schneggenburger, Daniel Keller, Olexiy Kochubey

Ca2+-dependent transmitter release occurs in a fast and in a slow phase, but the differential roles of Ca2+ buffers and Ca2+ sensors in shaping release kinetics are still controversial. Replacing extracellular Ca2+ by Sr2+ causes decreased fast release but ...

2014

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Thomas Heinis, Werner Alfons Hilda Van Geit, Rodrigo de Campos Perin, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Farhan Tauheed, Julian Charles Shillcock, Pramod Shivaji Kumbhar, Gilad Silberberg, Ying Shi, Vincent Delattre, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Jean-Vincent Le Bé, Julie Meystre, Taylor Howard Newton, Max Christian Nolte, Nicolas Antille, Georges Khazen, Sébastien Lasserre, Jean Pierre Ghobril, Jeffrey Christopher Muller, Aleksandr Ovcharenko, Shruti Muralidhar, Ahmet Bilgili, Daniel Nachbaur

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Daniel Keller, Srikanth Ramaswamy, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling

Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Judit Planas Carbonell, Nadir Roman Guerrero, Alessandro Enrico Foni, Georges Khazen, Elvis Boci, Adrien Christian Fleury, Juan José García Cantero

Understanding the intracellular dynamics of brain cells entails performing three-dimensional molecular simulations incorporating ultrastructural models that can capture cellular membrane geometries at nanometer scales. While there is an abundance of neuron ...

Oxford University Press (OUP)2024

A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

Daniel Keller

Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a ...

HUMANA PRESS INC2022

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Henry Markram, Daniel Keller, James Gonzalo King, James Bryden Isbister, Polina Shichkova, Darshan Mandge, Jean Nicolas Jacquemier, Alessandro Cattabiani

The high energetic demands of the brain arise primarily from neuronal activity. Neurons consume substantial energy to transmit information as electrical signals and maintain their resting membrane potential. These energetic requirements are met by the neur ...

Public Library of Science (PLoS)2025

Corrigendum: A Cell Atlas for the Mouse Brain

Henry Markram, Daniel Keller, Marc-Oliver Gewaltig, Csaba Erö

2019

Science and technology research and development in support to ITER and the Broader Approach at CEA

Yiming Li, Alexis Berne, Antoine Pierre Emmanuel Alexis Merle, Joan Decker, Yi Zhang, Jonathan Bryan Lister, Javier García Hernández, Daniel Keller, Fang Liu, Vincent Martin, Jonathan Bastien Cottet, Xiaoxia Bai

In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, ...

IOP Publishing Ltd2013

Seizure and redox rescue in a model of glucose transport deficiency

Henry Markram, Daniel Keller, Polina Shichkova

Disruptions of energy supply to the brain are associated with many neurodegenerative pathologies and are difficult to study due to numerous interlinked metabolic pathways. We explored the effects of diminished energy supply on brain metabolism using a comp ...

2025

Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex

Henry Markram, Giovanna Ambrosini, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Romain Guiet, Nicolas René Chiaruttini, Elvis Boci, Charlotte Lorin

The relation of astrocytic endfeet to the vasculature plays a key functional role in the neuro‐glia‐vasculature unit. We characterize the spatial organization of astrocytes and the structural aspects that facilitate their involvement in molecular exchanges ...

Wiley2024