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Olivier Pierre Zava

Cette personne a quitté l’EPFL

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Publications associées (33)

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Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]

Paul Joseph Dyson, Olivier Pierre Zava

Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and charac ...

Wiley-Blackwell2012

Encapsulation of Pyrene-Functionalized Poly(benzyl ether) Dendrons into a Water-Soluble Organometallic Cage

Olivier Pierre Zava

Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P-1 and P-2) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules enc ...

2011

Multinuclear Cytotoxic Metallodrugs: Physicochemical Characterization and Biological Properties of Novel Heteronuclear Gold-Titanium Complexes

Angela Casini, Olivier Pierre Zava, Michael Groessl

An unprecedented series of titanocene-gold bi- and trimetallic complexes of the general formula [(eta(5)-C5H5)-(mu-eta(5):kappa(1)-C5H4(CH2)(n)PPh2)TiCl2AuClx](q+) (n = 0, 2, or 4; m = 1, x =1, q = 0 or m = 2, x = 0, q = 1) have been prepared and char ...

2011

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Christian Hartinger, Wee Han Ang, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Albert Ruggi, Frédéric Schmitt, Julie Risse

Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite1,2-O-isopropylidene-alpha-D-glucofuranoside, were prepared in order to evaluate their ...

2012

Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity

Paul Joseph Dyson, Olivier Pierre Zava

The arene osmium metalla-prism (p-cymene)(6)Os-6(donq)(3)(tpt)(2) (2) (donq 5,8-dioxydo-1,4-naphthoquinonato, tpt 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine) has been prepared from the dinuclear arene osmium precursor [(p-cymene)(2)Os-2(donq)Cl-2] ...

Elsevier2012

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava

Gold(I) complexes bearing water-sol. phosphine ligands, including 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and sodium triphenylphosphine trisulfonate (TPPTS), in combination with thionate liga ...

Wiley-Blackwell2010

Thermoresponsive Chlorambucil Derivatives for Tumour Targeting

Paul Joseph Dyson, Alexey Nazarov, Olivier Pierre Zava, Catherine Marie Amélie Clavel, Frédéric Schmitt

Wiley-VCH Verlag GmbH2011

Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

Paul Joseph Dyson, Alexey Nazarov, Olivier Pierre Zava

New water-soluble 3,5,6-bicyclophosphite ligands based on glucose modified with uracil, 5-fluorouracil or thymine are reported. The phosphite ligands were subsequently reacted with bis[dichlorido(η6-p-cymene)ruthenium(II)] and trirutheniumdodecacarbonyl to ...

2020

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metalla ...

2012

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RA ...

2015

Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Olivier Pierre Zava

A series of p-cymene ruthenium dichloro complexes containing isonicotinic ester ligands, [(arene) RuCl2NC5H4-4-COO-C6H4-p-O-(CH2)(n)-CH3] (n = 1: 1, n = 3: 2, n = 5: 3, n = 7:4, n = 9: 5, n = 11: 6, n = 13: 7, n = 15: 8), were prepared from p-cymene ruthen ...

Elsevier2013

Anticancer activity of opened arene ruthenium metalla-assemblies

Paul Joseph Dyson, Olivier Pierre Zava

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)2Ru2(OO.intrsec.OO)2]2 ...

Royal Society of Chemistry2010

Multinuclear Cytotoxic Metallodrugs: Synthesis and Biological Studies of Novel Bimetallic Titanium-Ruthenium and Gold Complexes

Angela Casini, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl

Springer2014