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Francisco Javier Perez Saez

Cette personne a quitté l’EPFL

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Publications associées (21)

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Gene drives for schistosomiasis transmission control

Francisco Javier Perez Saez

Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas. Although mass drug administr ...

2019

A field-based modelling framework of the ecohydrology of schistosomiasis

Francisco Javier Perez Saez

Successful control of schistosomiasis, a water-borne parasitic disease, is challenged by the intricacy of the wormâ s lifecycle, which depends on aquatic snail intermediate hosts, and involves environmental, ecologic, and socio-economic factors. Current s ...

EPFL2018

A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission

Jean-Marc Fröhlich, Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Francisco Javier Perez Saez, Theophile Mande

We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly acco ...

Public Library of Science2015

Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland

Andrea Rinaldo, Jacques Fellay, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre

Following the rapid dissemination of COVID-19 cases in Switzerland, large-scale non-pharmaceutical interventions (NPIs) were implemented by the cantons and the federal government between 28 February and 20 March 2020. Estimates of the impact of these inter ...

2020

Comparative analysis of time-based and quadrat sampling in seasonal population dynamics of intermediate hosts of human schistosomes

Andrea Rinaldo, Francisco Javier Perez Saez, Theophile Mande

Background Despite their importance for designing and evaluating schistosomiasis control trials, little attention in the literature has been dedicated to sampling protocols for the parasite's snail intermediate hosts since their first development. We propo ...

2019

Space and time predictions of schistosomiasis snail host population dynamics across hydrologic regimes in Burkina Faso

Andrea Rinaldo, Francisco Javier Perez Saez, Theophile Mande

The ecology of the aquatic snails that serve as obligatory intermediate hosts of human schistosomiasis is driven by climatic and hydrological factors which result in specific spatial patterns of occurrence and abundance. These patterns in turn affect, join ...

2019

Earth and field observations underpin metapopulation dynamics in complex landscapes: Near-term study on carabids

Andrea Rinaldo, Francisco Javier Perez Saez, Damiano Pasetto, Jonathan Giezendanner

Understanding risks to biodiversity requires predictions of the spatial distribution of species adapting to changing ecosystems and, to that end, Earth observations integrating field surveys prove essential as they provide key numbers for assessing landsca ...

2020

Classification and prediction of river network ephemerality and its relevance for waterborne disease epidemiology

Andrea Rinaldo, Natalie Claire Ceperley, Francisco Javier Perez Saez, Theophile Mande

The transmission of waterborne diseases hinges on the interactions between hydrology and ecology of hosts, vectors and parasites, with the long-term absence of water constituting a strict lower bound. However, the link between spatio-temporal patterns of h ...

Elsevier Sci Ltd2017

Projected resurgence of COVID-19 in the United States in July-December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination

Francisco Javier Perez Saez

In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase the ri ...

eLIFE SCIENCES PUBL LTD2022

Modelled effects of prawn aquaculture on poverty alleviation and schistosomiasis control

Andrea Rinaldo, Lorenzo Mari, Francisco Javier Perez Saez

Recent evidence suggests that snail predators may aid efforts to control the human parasitic disease schistosomiasis by eating aquatic snail species that serve as intermediate hosts of the parasite. Here, potential synergies between schistosomiasis control ...

NATURE PUBLISHING GROUP2019

Hydrology and density feedbacks control the ecology of intermediate hosts of schistosomiasis across habitats in seasonal climates

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Francisco Javier Perez Saez, Theophile Mande

We report about field and theoretical studies on the ecology of the aquatic snails (Bulinus spp. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life cycle of the parasites causing human schistosomiasis. Snail abundance ...

Natl Acad Sciences2016

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

Didier Trono, Idris Guessous, Francisco Javier Perez Saez, Francesco Pennacchio

Limited data exist on SARS-CoV-2 infection rates across sectors and occupations, hindering our ability to make rational policy, including vaccination prioritization, to protect workers and limit SARS-CoV-2 spread. Here, we present results from our SEROCoV- ...

Nature Research2021

Characterizing human mobility patterns in rural settings of sub-Saharan Africa

Andrea Rinaldo, Francisco Javier Perez Saez, Theophile Mande

Human mobility is a core component of human behavior and its quantification is critical for understanding its impact on infectious disease transmission, traffic forecasting, access to resources and care, intervention strategies, and migratory flows. When m ...

eLIFE SCIENCES PUBL LTD2021

A scenario modeling pipeline for COVID-19 emergency planning

Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre

Coronavirus disease 2019 (COVID-19) has caused strain on health systems worldwide due to its high mortality rate and the large portion of cases requiring critical care and mechanical ventilation. During these uncertain times, public health decision makers, ...

Nature Portfolio2021

Heterogeneity in schistosomiasis transmission dynamics

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Francisco Javier Perez Saez

Simple models of disease propagation often disregard the effects of transmission heterogeneity on the ecological and epidemiological dynamics associated with host-parasite interactions. However, for some diseases like schistosomiasis, a widespread parasiti ...

Academic Press Ltd- Elsevier Science Ltd2017

Dataset - Kinetic-model-guided engineering of multiple S. cerevisiae strains improves p-coumaric acid production

Vassily Hatzimanikatis, Ljubisa Miskovic, Francisco Javier Perez Saez, Maria Masid Barcon, Bharath Narayanan, Wei Jiang

Dataset supporting the results presented in the paper entitled "Kinetic-model-guided engineering of multiple S. cerevisiae strains improves p-coumaric acid production" by Narayanan, Jiang & Wang et al (https://doi.org/10.1016/j.ymben.2025.06.008). Dataset ...

Zenodo2025

Modeling of Future COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Rates and Nonpharmaceutical Intervention Scenarios - United States, April-September 2021

Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre

CENTERS DISEASE CONTROL & PREVENTION2021

Rainfall as a driver of epidemic cholera: Comparative model assessments of the effect of intra-seasonal precipitation events

Andrea Rinaldo, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre, Damiano Pasetto

The correlation between cholera epidemics and climatic drivers, in particular seasonal tropical rainfall, has been studied in a variety of contexts owing to its documented relevance. Several mechanistic models of cholera transmission have included rainfall ...

2019

Climate-driven endemic cholera is modulated by human mobility in a megacity

Andrea Rinaldo, Francisco Javier Perez Saez

Although a differential sensitivity of cholera dynamics to climate variability has been reported in the spatially heterogeneous megacity of Dhaka, Bangladesh, the specific patterns of spread of the resulting risk within the city remain unclear. We build on ...

Elsevier2016

Incorporating the ecology of intermediate hosts of schistosomiasis into spatially explicit models of disease transmission in seasonal climates

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Francisco Javier Perez Saez, Theophile Mande

Wiley2017