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Electrospray ionization mass spectrometry (ESI-MS) is a powerful tool to investigate large molecules. Miniaturized microchips, as a goal of ‘Lab-on-chip’, allow various integrated analysis quickly. The coupling of functional microchips and ESI-MS is capabl ...

The complexation reactions between strontium (Sr2+) and octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (CMPO) were studied at the aqueous vertical bar 1,2-dichloroethane (w vertical bar DCE) and aqueous vertical bar room-temperature ionic liqui ...

alpha-Synuclein (alpha-syn) is a 140-amino acid protein that plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. However, the molecular determinants that are responsible for triggering and/or propagating alpha- ...

Melittin, a membrane-active peptide with antimicrobial activity, was investigated at the interface formed between two immiscible electrolyte solutions (ITIES) supported on a metallic electrode. Ion-transfer voltammetry showed well-defined semi-reversible t ...

Tyrosine nitration, often observed during neurodegenerative disorders under nitrative stress, is usually considered to be induced chemically either by nitric oxide and oxygen forming nitrogen dioxide or by the decomposition of peroxynitrite. It can also be ...

Enhanced charging, or supercharging, of analytes in electrospray ionization mass spectrometry (ESI MS) facilitates high resolution MS by reducing an ion mass-to-charge (m/z) ratio, increasing tandem mass spectrometry (MS/MS) efficiency. ESI MS superchargin ...

Copper-b-amyloid 16 (Aβ16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(I) and (II) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in posit ...

An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, ...

A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous ...

Yu Lu

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Microchip Based Electrospray Mass Spectrometry for Investigation of Neurodegenerative Peptides

Interfacial Complexation Reactions of Sr2+ with Octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine Oxide for Understanding Its Extraction in Reprocessing Spent Nuclear Fuels

Phosphorylation of alpha-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of alpha-Synuclein in the Pathogenesis of Parkinson's Disease and Related Disorders

Melittin Adsorption and Lipid Monolayer Disruption at Liquid-Liquid Interfaces

Copper-Catalyzed Tyrosine Nitration

In-Spray Supercharging of Peptides and Proteins in Electrospray Ionization Mass Spectrometry

Copper(I) and copper(II) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

Electrostatic-Spray Ionization Mass Spectrometry

Dual-Channel Electrospray Microchip