Kristina Schoonjans

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Publications associées (109)

Emerging actions of the nuclear receptor LRH-1 in the gut

Kristina Schoonjans, Johan Auwerx, Pablo Jose Fernandez Marcos

Liver receptor homolog-1 (NR5A2) is a nuclear receptor originally identified in the liver and mostly known for its regulatory role in cholesterol and bile acid homeostasis. More recently, liver receptor homolog-1 has emerged as a key regulator of intestina ...

2011

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

Kristina Schoonjans, Johan Auwerx

BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...

2010

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

Kristina Schoonjans, Chikage Mataki

Milona A, Owen BM, van Mil S, Dormann D, Mataki C, Boudjelal M, Cairns W, Schoonjans K, Milligan S, Parker M, White R, Williamson C. The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J P ...

2010

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Kristina Schoonjans, Johan Auwerx

Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine resi ...

Cell Press2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Kristina Schoonjans, Johan Auwerx, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Kristina Schoonjans, Johan Auwerx, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

Kristina Schoonjans, Johan Auwerx

Wiley-Blackwell2010

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

Kristina Schoonjans, Johan Auwerx

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...

American Society for Clinical Investigation2009

Targeting bile-acid signalling for metabolic diseases

Kristina Schoonjans, Johan Auwerx

Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis. It is therefore not surprising that a number of bile-acid-activated sig ...

2008

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