Recherche

Afficher tous les résultats pour

Accueil

Personne

Jacques Rougemont

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (46)

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Felix Naef, Nicolas Jean Philippe Guex, Olivier Martin, Mauro Delorenzi, Nouria Hernandez, Bart Deplancke, Jacques Rougemont, Laura Symul, Winship Herr

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis

Stewart Cole, Claudia Sala, Swapna Uplekar, Jacques Rougemont, Ruben Hartkoorn, Philippe Busso

In Mycobacterium tuberculosis the alternative sigma factor SigF controls the expression of a particular subset of genes by altering RNA polymerase specificity. Here, we utilize two genome-wide approaches to identify SigF-binding sites: chromatin immunoprec ...

American Society for Microbiology2012

Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling

Jacques Rougemont, Christian Fankhauser, Ioannis Xenarios

Plant growth is strongly influenced by the presence of neighbors that compete for light resources. In response to vegetational shading shade-intolerant plants such as Arabidopsis display a suite of developmental responses known as the shade-avoidance syndr ...

Wiley-Blackwell2012

Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

Cathrin Brisken, Ayyakkannu Ayyanan, Jacques Rougemont, Tamara Tanos, Christina Schrick

Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently utilize ...

Endocrine Society2011

Analysis of HIV-1 Expression Level and Sense of Transcription by High-Throughput Sequencing of the Infected Cell

Jacques Rougemont, Amalio Telenti

Next-generation sequencing offers an unprecedented opportunity to jointly analyze cellular and viral transcriptional activity without prerequisite knowledge of the nature of the transcripts. SupT1 cells were infected with a vesicular stomatitis virus G env ...

American Society for Microbiology2011

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

Stewart Cole, Swapna Uplekar, Jacques Rougemont

The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vacc ...

2011

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

Felix Naef, Guillaume Rey, Jacques Rougemont

The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian clock, the ...

2011

A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

Philipp Bucher, Didier Trono, Sylvain Meylan, Anna Claire Groner, Annamaria Kauzlaric, Giovanna Ambrosini, Adamantia Kapopoulou, Jacques Rougemont, Nadine Fournier

BACKGROUND: KRAB-ZFPs (Kruppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors respo ...

BioMed Central2011

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Carine Delattre-Gubelmann, Bart Deplancke, Jacques Rougemont, Alexandre Gattiker, Fabrice David, Andreas Massouras, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

Computational analysis of protein-DNA interactions from ChIP-seq data

Felix Naef, Jacques Rougemont

Chromatin immunoprecipitation experiments followed by ultra-high-throughput sequencing (ChIP-seq) is becoming the method of choice to identify transcription factor binding sites in prokaryotes and eukaryotes in vivo. Here, we review the computational steps ...

2011

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

Jacques Rougemont

TORC1 is a conserved multisubunit kinase complex that regulates many aspects of eukaryotic growth including the biosynthesis of ribosomes. The TOR protein kinase resident in TORC1 is responsive to environmental cues and is potently inhibited by the natural ...

2011

Probable zoonotic leprosy in the southern United States

Stewart Cole, Adamantia Kapopoulou, Jacques Rougemont, Philippe Busso, Pushpendra Singh, Rahul Sharma

In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure. In the same region, as well as in Mexico, wild armadillos are infected wi ...

2011

Stabilizing patterning in the Drosophila segment polarity network by selecting models in silico

Felix Naef, Mirko Bischofberger, Jacques Rougemont

The segmentation of Drosophila is a prime model to study spatial patterning during embryogenesis. The spatial expression of segment polarity genes results from a complex network of interacting proteins whose expression products are maintained after success ...

Elsevier2010

KAP1 controls endogenous retroviruses in embryonic stem cells

Didier Trono, Daniel Constam, Pierre Maillard, Séverine Reynard, Johan Jakobsson, Sonia Verp, Helen Mary Rowe, Jacques Rougemont, Hillary Layard-Liesching

More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-ty ...

Nature Publishing Group2010

The telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae

Felix Naef, Jacques Rougemont, Enrico Guarnera

Small nucleolar RNAs (snoRNAs) play a key role in ribosomal RNA biogenesis, yet factors controlling their expression are unknown. We found that the majority of Saccharomyces snoRNA promoters display an aRCCCTaa sequence motif at the upstream border of a TA ...

Elsevier2010

Processing and analyzing ChIP-seq data: from short reads to regulatory interactions

Jacques Rougemont, Marion Leleu

Chromatin-immunoprecipitation and sequencing (ChIP-seq) is a rapidly maturing technology that draws on the power of high-throughput short-read sequencing to decipher chromatin states with unprecedented precision and breadth. Although some aspects of the ex ...

2010

Primer-initiated sequence synthesis to detect and assemble structural variants

Carine Delattre-Gubelmann, Stewart Cole, Swapna Uplekar, Bart Deplancke, Jacques Rougemont, Andreas Massouras, Frederik Decouttere

Nature Publishing Group2010

The Microbe browser for comparative genomics

Jacques Rougemont, Alexandre Gattiker, Marco Pagni, Ioannis Xenarios

The Microbe browser is a web server providing comparative microbial genomics data. It offers comprehensive, integrated data from GenBank, RefSeq, UniProt, InterPro, Gene Ontology and the Orthologs Matrix Project (OMA) database, displayed along with gene pr ...

Oxford University Press2009

Comparative genomic and phylogeographic analysis of Mycobacterium leprae

Stewart Cole, Jacques Rougemont, Alexandre Gattiker, Philippe Busso, Pushpendra Singh

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained b ...

2009

A Rapid Bootstrap Algorithm for the RAxML Web Servers

Alexandros Stamatakis, Jacques Rougemont

Despite recent advances achieved by application of high-performance computing methods and novel algorithmic techniques to maximum likelihood (ML)-based inference programs, the major computational bottleneck still consists in the computation of bootstrap su ...

Taylor and Francis, Oxford2008

Page 2 sur 3