Publications de Kui Thong Tan | EPFL Graph Search

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Progress in understanding signal transduction and metabolic pathways is hampered by a shortage of suitable sensors for tracking metabolites, second messengers, and neurotransmitters in living cells. Here we introduce a class of rationally designed semisynt ...

Genetically encoded fluorescent sensor proteins offer the possibility to probe the concentration of key metabolites in living cells. The approaches currently used to generate Such fluorescent sensor proteins lack. generality, as they require a protein that ...

We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given class of compounds into a fluorescent biosensor. By measuring the binding of dif ...

We report the semisynthesis of a fluorescent glutamate sensor protein on cell surfaces. Sensor excitation at 547 nm yields a glutamate-dependent emission spectrum between 550 and 700 nm that can be exploited for ratiometric sensing. On cells, the sensor di ...

Kui Thong Tan

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Semisynthesis of fluorescent metabolite sensors on cell surfaces

Semisynthetic fluorescent sensor proteins based on self-labeling protein tags

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

A Semisynthetic Fluorescent Sensor Protein for Glutamate