Recherche

Afficher tous les résultats pour

Accueil

Personne

Stewart Cole

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (266)

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

Stewart Cole

Mycobacterium leprae protein ML2640c belongs to a large family of conserved hypothetical proteins predominantly found in mycobacteria, some of them predicted as putative S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTase). As part of a Struc ...

2007

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

Stewart Cole, Pablo Fernandez

Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence suggests that Ser/Thr phosphorylation play important roles in the physiology and ...

2007

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis

Petra Tafelmeyer, Stewart Cole

The role of biofilms in the pathogenesis of mycobacterial diseases remains largely unknown. Mycobacterium ulcerans, the etiological agent of Buruli ulcer, a disfiguring disease in humans, adopts a biofilm-like structure in vitro and in vivo, displaying an ...

2007

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

Stewart Cole

The 6-kDa early secreted antigenic target ESAT-6 and the 10-kDa culture filtrate protein CFP-10 of Mycobacterium tuberculosis are secreted by the ESX-1 system into the host cell and thereby contribute to pathogenicity. Although different studies performed ...

American Society for Microbiology2007

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone

Stewart Cole

Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). Surprisingly, infected tissues lack inflammatory infiltrates. Structural similarities between mycolactone and immunosuppre ...

2007

New approaches to filling the gap in tuberculosis drug discovery

Stewart Cole

2007

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Stewart Cole

Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous tissue that is rampant throughout West and Central Africa. Here, we report the complete 5.8-Mb genome sequ ...

2007

Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva

Stewart Cole

BACKGROUND: Buruli ulcer is a severe human skin disease caused by Mycobacterium ulcerans. This disease is primarily diagnosed in West Africa with increasing incidence. Antimycobacterial drug therapy is relatively effective during the preulcerative stage of ...

2007

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

Stewart Cole

We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infect ...

2007

Search for lepton and baryon number violating τ- decays into Λ̄π- and Λπ-

Olivier Schneider, Sun Hee Kim, Tagir Aushev, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang, Ji Hyun Kim

We have searched for τ lepton decays, τ-→Λ̄π- and τ-→Λπ-, that simultaneously violate the conservation of the lepton (L) and baryon (B) number using a data sample of 154 fb-1 collected with the Belle detector at the KEKB e+e- asymmetric-energy collider. No ...

2006

Search for lepton flavor violating τ- decays with a KS 0 meson

Olivier Schneider, Tagir Aushev, Stewart Cole, Chao Wang, Lei Zhang

We have searched for the lepton flavor violating decays τ- → ℓ- KS 0 (ℓ = e or μ), using a data sample of 281 fb-1 collected with the Belle detector at the KEKB e+ e- asymmetric-energy collider. No evidence for a signal was found in either of the decay mod ...

2006

Search for neutrinoless decays τ → ℓ h h and τ → ℓ V0

Aurelio Bay, Olivier Schneider, Sun Hee Kim, Stewart Cole

We have searched for neutrinoless τ lepton decays into ℓhh or ℓ V0, where ℓ stands for an electron or muon, h for a charged light hadron, π or K, and V0 for a neutral vector meson, ρ0, K* (892)0 and φ{symbol}, using a 158 fb-1 data sample collected with th ...

2006

Measurement of the branching fraction, polarization, and CP asymmetry for B0→ρ+ρ- Decays, and determination of the cabibbo-kobayashi-maskawa phase 2

Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang, Jing Li

We have measured the branching fraction B, longitudinal polarization fraction fL, and CP asymmetry coefficients A and S for B0→ρ+ρ- decays with the Belle detector at the KEKB e+e- collider using 253fb-1 of data. We obtain B=[22.8±3.8(stat)-2.6+2.3(syst)]×1 ...

2006

Study of decay mechanisms in B-→Λc+p̄π- decays and observation of low-mass structure in the Λc+p̄ system

Sun Hee Kim, Tagir Aushev, Stewart Cole, Sanjeev Kumar

Using a sample of 152×106 BB̄ pairs accumulated with the Belle detector at the KEKB e+e- collider, we study the decay mechanism of three-body charmed decay B-→Λc+p̄π-. The intermediate two-body decay B-→Σc(2455)0p̄ is observed for the first time with a bra ...

2006

Observation of b→dγ and determination of |Vtd/Vts|

Sun Hee Kim, Tagir Aushev, Stewart Cole, Vladislav Balagura

We report the observation of the flavor-changing neutral current process b→dγ using a sample of 386×106 B meson pairs accumulated by the Belle detector at the KEKB e+e- collider. We measure branching fractions for the exclusive modes B-→ρ-γ, B̄0→ρ0γ, and B ...

2006

Search for the decay B0→γγ

Christian Jacoby, Jean Wicht, Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang

The rare decay B0→γγ is searched for in 104fb-1 of data, corresponding to 111×106BB̄ pairs, collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. No evidence for the signal is found, and an upper limit of 6.2×10-7 at 90% confidence ...

American Physical Society2006

Evidence of the purely leptonic decay B-→τ-ν̄τ

Aurelio Bay, Tagir Aushev, Stewart Cole, Vladislav Balagura

We present the first evidence of the decay B-→τ-ν̄τ, using 414fb-1 of data collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. Events are tagged by fully reconstructing one of the B mesons in hadronic modes ...

2006

Evidence for B→η^{′}π and Improved Measurements for B→η^{′}K

Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang

2006

Measurement of D0→πlν(Klν) Form Factors and Absolute Branching Fractions

Aurelio Bay, Olivier Schneider, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang, Jing Li

2006

Measurement of the Quark Mixing Parameter cos⁡2ϕ_{1} Using Time-Dependent Dalitz Analysis of B[over ¯]^{0}→D[K_{S}^{0}π^{+}π^{-}]h^{0}

Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang, Jing Li

2006

Page 12 sur 14