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Stewart Cole

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Publications associées (266)

Lack of Insertional-Deletional Polymorphism in a Collection of Mycobacterium ulcerans Isolates from Ghanaian Buruli Ulcer Patients

Stewart Cole, Julia Hauser

Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomorphic population structure. The resolution of conventional genetic fingerprinting methods is therefore not sufficient for microepidemiological studies aiming ...

American Society for Microbiology2009

Study of the decay mechanism for B+ -> p(p)over-barK(+) and B+ -> p(p)over-bar pi(+)

Aurelio Bay, Olivier Schneider, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura

We study the characteristics of the low mass p (p) over bar enhancements near threshold in the three-body decays B+ -> p (p) over barK(+) and B+ -> p (p) over bar pi(+). We observe that the proton polar angle distributions in the p (p) over bar helicity fr ...

2008

Study of B→D**lν with full reconstruction tagging

Aurelio Bay, Olivier Schneider, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Xiao Wang

American Physical Society2008

Difference in direct charge-parity violation between charged and neutral B meson decays

Jean Wicht, Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Jing Li

2008

New medicines for tuberculosis (NM4TB)

Stewart Cole

2008

Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR

Stewart Cole, Iain Old

BACKGROUND: Phi29 polymerase based amplification methods provides amplified DNA with minimal changes in sequence and relative abundance for many biomedical applications. RNA virus detection using microarrays, however, can present a challenge because phi29 ...

2008

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

Stewart Cole

Buruli ulcer is an emerging human disease caused by infection with a slow-growing pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with immunomodulatory properties. The disease is associated with wetlands in certain tropical countri ...

2008

Rising standards for tuberculosis drug development

Stewart Cole

Development of new drugs to treat tuberculosis (TB) faces even more constraints than the development of therapeutic agents for other diseases. This is due, in part, to intrinsic properties of the tubercle bacillus, such as its slow growth, phenotypic drug ...

2008

A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling

Stewart Cole, Edina Rita Székely, Gabor Nemeth

The Mycobacterium tuberculosis genome encodes for eleven eukaryotic-like Ser/Thr protein kinases. At least three of these (PknA, PknB and PknG) are essential for bacterial growth and survival. PknG is secreted by pathogenic mycobacteria, in macrophages to ...

2008

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

Stewart Cole

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5 ...

2008

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

Stewart Cole

Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful approach to identify yet unknown virulence determinants and pathways involved in tuberculosis pathogenesis. Two of the most widely used attenuated strains in the ...

2008

Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis

Petra Tafelmeyer, Stewart Cole

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a rapidly emerging human disease in which mycolactone, a cytotoxic and immunosuppressive macrocyclic polyketide, is responsible for massive skin destruction. The genome sequencing of M. ulceran ...

2008

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?

Stewart Cole

Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. l ...

2008

Characterization of active site structure in CYP121: A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv

Stewart Cole

Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by gene knock-out with complementation. Production of CYP121 protein in Mtb cells is demonstrated. Minimum inhibitory concentratio ...

2008

A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial

Stewart Cole

From the structure of 3,3-dimethyl-3H-benzofuro[3,2-f][1]-benzopyran, a selective in vitro inhibitor of mycobacterial growth, we have undertaken a structure-activity relationship investigation. We wish to report here our results on the use of [2+3] cycload ...

2008

Observation of the decay B̄0→Ds+Λp̄

Aurelio Bay, Olivier Schneider, Tagir Aushev, Stewart Cole, Chao Wang, Vladislav Balagura

We report the first observation of the decay B̄0→Ds+Λ p̄ with a statistical significance of 6.6σ. We measure B(B̄0→Ds+Λp̄)=(2.9±0.7±0.5±0.4) ×10-5, where the first error is statistical, the second is systematic, and the third error comes from the uncertain ...

American Physical Society2007

Evidence for D0-D̄0 mixing

Jean Wicht, Aurelio Bay, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Yuan Yuan, Vladislav Balagura, Lei Zhang, Jing Li

We observe evidence for D0-D̄0 mixing by measuring the difference in the apparent lifetime when a D0 meson decays to the CP eigenstates K+K- and π+π- and when it decays to the final state K-π+. We find the relative difference of the lifetimes yCP to be [1. ...

2007

Search for b→h(*)νν̄ decays at belle

Aurelio Bay, Olivier Schneider, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura

We present a search for the rare decays B→h()νν̄, where h() stands for a light meson. A data sample of 535×106 BB̄ pairs collected with the Belle detector at the KEKB e+e- collider is used. Signal candidates are required to have an accompanying B meson f ...

2007

Measurements of branching fractions and q2 distributions for B → π ℓ ν and B → ρ ℓ ν decays with B → D(*) ℓ ν decay tagging

Aurelio Bay, Olivier Schneider, Tagir Aushev, Mingkui Wang, Stewart Cole, Chao Wang, Vladislav Balagura, Lei Zhang, Jing Li

We report measurements of the charmless semileptonic decays B0 → π- / ρ- ℓ+ ν and B+ → π0 / ρ0 ℓ+ ν, based on a sample of 2.75 × 108B over(B, ̄) events collected at the Υ{hooked} (4 S) resonance with the Belle detector at the KEKB e+ e- asymmetric collider ...

2007

Moments of the electron energy spectrum and partial branching fraction of B→Xceν decays at the Belle detector

Olivier Schneider, Sun Hee Kim, Tagir Aushev, Stewart Cole, Chao Wang, Lei Zhang, Jing Li

We report a measurement of the inclusive electron energy spectrum for charmed semileptonic decays of B mesons in a 140fb-1 data sample collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric energy e+e- collider. We determine the fi ...

American Physical Society2007

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