Publications de Chiara Gabella

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The mechanical interaction between adherent cells and their substrate relies on the formation of adhesion sites and on the stabilization of contractile acto-myosin bundles, or stress fibers. The shape of the cell and the orientation of these fibers can be ...

Cell migration is a fundamental process in all animal cells. The ability of cell to migrate is crucial for many pathological and physiological conditions such as morphogenesis, the immune response to inflammatory or vascular diseases and cancer metastasis. ...

This survey investigates Research Data Management (RDM) practices across five Swiss higher education institutions, including EPFL, ETH Zürich, Eawag, FHNW, and DaSCH, with the goal of gathering insights into how researchers manage data and code throughout ...

We propose a new technique to measure the volume of adherent migrating cells. The method is based on a negative staining where a fluorescent, non-cell-permeant dye is added to the extracellular medium. The specimen is observed with a conventional fluoresce ...

Actin-myosin filament bundles (stress fibers) are critical for tension generation and cell shape, but their mechanical properties are difficult to access. Here we propose a novel approach to probe individual peripheral stress fibers in living cells through ...

Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membr ...

Actin-myosin microfilament bundles or stress-fibers are the principal tension-generating structures in the cell. Their mechanical properties are critical for cell shape, motion, and interaction with other cells and extracellular matrix, but were so far dif ...

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

This survey aims to investigate research data management practices at EPFL and integrate their results into specific academic services. The previous two editions, in collaboration with TU Delft, Cambridge University and Illinois University, were carried ou ...

Chiara Gabella

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Cell Shape Dynamics Reveal Balance of Elasticity and Contractility in Peripheral Arcs

Interplay between cytoskeletal forces, membrane tension and shape in rapidly migrating cells

Quantitative Assessment of Research Data Management Practices - 2023

Dynamic measurement of the height and volume of migrating cells by a novel fluorescence microscopy technique

Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

Ultra-soft cantilevers and 3-D micro-patterned substrates for contractile bundle tension measurement in living cells

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells

Quantitative assessment of research data management practice - 2021

Interplay between cytoskeletal forces, membrane tension, and hydrostatic pressure in rapidly migrating cells